Effect of uterotonics on intra-operative blood loss during laparoscopy-assisted vaginal hysterectomy: A randomised controlled trial

Fung W. Chang, Mu Hsien Yu, Chih Hung Ku, Chi Huang Chen, Gwo Jang Wu, Jah Y. Liu

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

Objective: To investigate the effectiveness of uterotonics misoprostol and oxytocin on reducing blood loss during laparoscopy-assisted vaginal hysterectomy (LAVH). Design: Randomised, double-blind placebo-controlled trial. Setting: University hospital. Population: One hundred and seventy-three women underwent LAVH for symptomatic uterine myomas and were randomly allocated to uterotonics (n= 91) or placebo (n= 82). Methods: Women underwent LAVH for symptomatic uterine myomas and were randomly assigned to receive either rectal misoprostol (400 μg) and intravenous oxytocin (10 IU/hour) or placebo during LAVH. Parameters related to surgical outcome were compared. Main outcome measures: The main outcome measure was intra-operative blood loss. Results: Patient characteristics and indications for LAVH were similar in both groups. Mean [SD] for all continuous data estimated weight of blood loss (198.1 [123.2] vs 396 [337.6] g; P <0.0001), mean operation time (106.2 [39.4] vs 116.6 [34.6] minutes; P= 0.02), mean change in haemoglobin (1.5 [1.0] vs 1.9 [1.2] g/dL; P= 0.02) and haematocrit levels (4.8 [2.9]% vs 5.8 [3.6]%; P= 0.04) and mean hospitalisation period (3.3 [0.8] vs 3.9 [1.1] days; P <0.0001), which were significantly less in the group given rectal misoprostol and intravenous oxytocin than in the placebo group, respectively. There was no significant difference in complications and side effects between the two groups (P > 0.05). Conclusion: Combined rectal misoprostol and intravenous oxytocin is a feasible and effective method of reducing blood loss and operation time in LAVH.

原文英語
頁(從 - 到)47-52
頁數6
期刊BJOG: An International Journal of Obstetrics and Gynaecology
113
發行號1
DOIs
出版狀態已發佈 - 一月 2006
對外發佈

ASJC Scopus subject areas

  • 婦產科

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