Effect of trilinolein on the activity and gene expression of superoxide dismutase in cultured rat brain astrocytes

Wen Ta Chiu, Paul Chan, Shue Sen Liao, Jyh Ren Liou, Juei Tang Cheng

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

摘要

Cerebrovascular disease is one of the major causes of morbidity and mortality in recent. Oxygen free radicals produced during cerebral infarction increases the damage to neurons. Superoxide dismutase (SOD) is the endogenous antioxidant enzyme that can effectively scavenge superoxide radicals. Trilinolein is a lipophilic antioxidant purified from the herb of Panax pseudoginseng. In the cultured rat brain astrocytes (RBA), the activity of SOD (both Cu,Zn-SOD and Mn-SOD subtypes) was markedly increased by incubation with trilinolein at low concentration (0.1 μM) for 2 days. This stimulatory effect of trilinolein was not related to the incubating concentration. However, long-term (7 days) incubation with trilinolein at same concentration decreased the activity. Similar changes were also observed in the gene expression of SOD in RBA; short-term (2 days) incubation of RBA by 0.1 μM trilinolein increased the mRNA level that was lowered in RBA received a long- term incubation with 0.1 μM trilinolein. This result shows that trilinolein is an effective antioxidant to increase the activity of SOD in RBA which would be beneficial to neurons subjected to oxygen free radical damage. However, long-term medication of antioxidant shall be concerned.

原文英語
頁(從 - 到)17-20
頁數4
期刊Neuroscience Letters
269
發行號1
DOIs
出版狀態已發佈 - 七月 2 1999

ASJC Scopus subject areas

  • Neuroscience(all)

指紋 深入研究「Effect of trilinolein on the activity and gene expression of superoxide dismutase in cultured rat brain astrocytes」主題。共同形成了獨特的指紋。

  • 引用此