Effect of trilinolein on superoxide dismutase activity and left ventricular pressure in isolated rat hearts subjected to hypoxia and normoxic perfusion

Paul Chan, Chiang Shan Niu, Brian Tomlinson, Chi Tzong Hong, Jane Pyng Chen, Chuang Ye Hong, Shen Kou Tsai, Juei Tang Cheng

研究成果: 雜誌貢獻文章

19 引文 斯高帕斯(Scopus)

摘要

Oxygen-derived free radicals have been implicated in the development of myocardial injury during hypoxia/reperfusion. Antioxidants can effectively inhibit the formation of free radicals and ameliorate the myocardial damage which may occur during hypoxia/reperfusion. Trilinolein is a triacylglycerol recently purified from the traditional Chinese medicinal plant Panax pseudo-ginseng. It has linoleic-acid residues as the only type of fatty acid residue in all three esterified positions of the triacyglycerol, It has been proposed that decreased endogenous superoxide dismutase (SOD) activity may contribute to free radical-mediated reperfusion injury of the ischemic myocardium. In the present study, when isolated rat hearts were subjected to hypoxia for 10, 30, 60 and 90 min without normoxic perfusion, a significant decrease in Mn-SOD activity was shown throughout the period of hypoxia, whereas the Cu·Zn-SOD activity was increased at 10 and 30 min but was not different from the baseline at 60 and 90 min of hypoxia. In rat hearts pretreated with 10 -7 mol/l trilinolein and subjected to 60 min of hypoxia without normoxic perfusion, Cu·Zn-SOD was augmented compared with baseline and compared with hearts subjected to 60 min of hypoxia without trilinolein, whereas Mn-SOD activity was still reduced compared with baseline, although less so than after 60 min of hypoxia without trilinolein. Pretreatment with trilinolein was associated with better preservation of left ventricular function during hypoxia and more rapid return to recovery during normoxic perfusion. This myocardial protective effect may be related to an antioxidant effect through potentiation of SOD, particularly Cu·Zn-SOD during hypoxia.

原文英語
頁(從 - 到)252-258
頁數7
期刊Pharmacology
55
發行號5
出版狀態已發佈 - 十一月 1997

ASJC Scopus subject areas

  • Pharmacology

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    Chan, P., Niu, C. S., Tomlinson, B., Hong, C. T., Chen, J. P., Hong, C. Y., Tsai, S. K., & Cheng, J. T. (1997). Effect of trilinolein on superoxide dismutase activity and left ventricular pressure in isolated rat hearts subjected to hypoxia and normoxic perfusion. Pharmacology, 55(5), 252-258.