Effect of topiramate on intractable seizures in Taiwanese children

Sung Tse Li, Ein Yiao Shen, Nan Chang Chiu, Che Sheng Ho

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

We performed a prospective study to evaluate the effect of topiramate as an adjunctive therapy in Taiwanese children with intractable partial epilepsy and generalized epilepsy. Thirty children aged from 2 to 16 years (8.5 ± 3.8 years) were enrolled in this study. Eighteen children (60.0%) had partial epilepsy, and 12 children (40.0%) had generalized epilepsy. These children were experiencing more than one seizure per month even under a stable antiepileptic regimen treatment. Topiramate was begun at 1 mg/kg·day, and the dosage was raised by 1 mg/kg·day each week. Titration continued for 4 weeks or more. The maximal dosage was 10 mg/kg·day. In children with partial epilepsy, six children (33.3%) achieved ≥ 50% frequency reduction, while eight children (44.4%) achieved a seizure-free state. In children with generalized epilepsy, including infantile spasms, four children (33.3%) achieved ≥ 50% frequency reduction, while five children (41.7%) achieved a seizure-free state. The most common adverse effect was poor appetite (10.0%). No idiosyncratic reactions to topiramate were found. Only one patient discontinued topiramate because of central hyperventilation. Topiramate can be used as an adjunctive antiepileptic drug for intractable epileptic children in Taiwan.
原文英語
頁(從 - 到)59-63
頁數5
期刊Acta Neurologica Taiwanica
13
發行號2
出版狀態已發佈 - 六月 2004

ASJC Scopus subject areas

  • 神經病學(臨床)

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