Effect of soya protein on serum lipid profile and lipoprotein concentrations in patients undergoing hypercholesterolaemic haemodialysis

Shu Tzu Chen, Jiun-Rong Chen, Chwei Shiun Yang, Sheng Jeng Peng, Shyang H. Feng

研究成果: 雜誌貢獻文章同行評審

27 引文 斯高帕斯(Scopus)

摘要

Clinical trials have shown that soya protein reduces the concentrations of some atherogenic lipids in subjects with normal renal function. The present study examined the effects of soya protein on serum lipid concentrations and lipoprotein metabolism in patients on hypercholesterolaemic haemodialysis. Twenty-six hypercholesterolaemic (total cholesterol ≥ 6.21 mmol/l) patients on haemodialysis were studied in a randomized, double-blind, placebo-controlled clinical trial. After a 4-week run-in phase, the subjects were randomly assigned to two groups. Isolated soya protein or milk protein 30g was consumed daily as a beverage at breakfast or post-dialysis for 12 weeks. Soya protein substitution resulted in significant reductions in total cholesterol (17.2 (SD 8.9)%), LDL-cholesterol (15.3 (SD 12.5)%), apo B (14.6 (SD 12.1)%) and insulin (23.8 (SD 18.7)%) concentrations. There were no significant changes in HDL-cholesterol or apo A-I. These results indicate that replacing part of the daily protein intake with soya protein has a beneficial effect on atherogenic lipids and favourably affects lipoprotein metabolism in hypercholesterolaemic patients undergoing haemodialysis.
原文英語
頁(從 - 到)366-371
頁數6
期刊British Journal of Nutrition
95
發行號2
DOIs
出版狀態已發佈 - 二月 2006

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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