Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features

Tsung Te Chung, Chao Bin Yeh, Yi Ching Li, Shih Chi Su, Ming Hsien Chien, Shun Fa Yang, Yi Hsien Hsieh

研究成果: 雜誌貢獻文章

18 引文 (Scopus)

摘要

Background: The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) down-regulation has been confirmed in numerous human cancers and is clinically associated with metastasis. This study investigates the potential associations of RECK single-nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC) susceptibility and its clinicopathologic characteristics. Methodology/Principal Findings: A total of 135 HCC cancer patients and 501 cancer-free controls were analyzed for four RECK SNPs (rs10814325, rs16932912, rs11788747, and rs10972727) using real-time PCR and PCR-RFLP genotyping analysis. After adjusting for other co-variants, the individuals carrying RECK promoter rs10814325 inheriting at least one C allele had a 1.85-fold [95% confidence interval (CI), 1.03-3.36] risk of developing HCC compared to TT wild type carriers. The HCC patients, who carried rs11788747 with at least one G allele, had a higher distant metastasis risk than wild type probands. Conclusions: RECK gene polymorphisms might be a risk factor increasing HCC susceptibility and distant metastasis in Taiwan.

原文英語
文章編號e33517
期刊PLoS One
7
發行號3
DOIs
出版狀態已發佈 - 三月 12 2012

指紋

hepatoma
Polymorphism
Hepatocellular Carcinoma
Genes
genetic polymorphism
metastasis
Nucleotides
Neoplasm Metastasis
genes
single nucleotide polymorphism
neoplasms
Single Nucleotide Polymorphism
Alleles
Cysteine
alleles
Liver Neoplasms
Taiwan
Restriction Fragment Length Polymorphisms
genotyping
cysteine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

引用此文

Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features. / Chung, Tsung Te; Yeh, Chao Bin; Li, Yi Ching; Su, Shih Chi; Chien, Ming Hsien; Yang, Shun Fa; Hsieh, Yi Hsien.

於: PLoS One, 卷 7, 編號 3, e33517, 12.03.2012.

研究成果: 雜誌貢獻文章

Chung, Tsung Te ; Yeh, Chao Bin ; Li, Yi Ching ; Su, Shih Chi ; Chien, Ming Hsien ; Yang, Shun Fa ; Hsieh, Yi Hsien. / Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features. 於: PLoS One. 2012 ; 卷 7, 編號 3.
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abstract = "Background: The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) down-regulation has been confirmed in numerous human cancers and is clinically associated with metastasis. This study investigates the potential associations of RECK single-nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC) susceptibility and its clinicopathologic characteristics. Methodology/Principal Findings: A total of 135 HCC cancer patients and 501 cancer-free controls were analyzed for four RECK SNPs (rs10814325, rs16932912, rs11788747, and rs10972727) using real-time PCR and PCR-RFLP genotyping analysis. After adjusting for other co-variants, the individuals carrying RECK promoter rs10814325 inheriting at least one C allele had a 1.85-fold [95{\%} confidence interval (CI), 1.03-3.36] risk of developing HCC compared to TT wild type carriers. The HCC patients, who carried rs11788747 with at least one G allele, had a higher distant metastasis risk than wild type probands. Conclusions: RECK gene polymorphisms might be a risk factor increasing HCC susceptibility and distant metastasis in Taiwan.",
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AU - Chien, Ming Hsien

AU - Yang, Shun Fa

AU - Hsieh, Yi Hsien

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N2 - Background: The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) down-regulation has been confirmed in numerous human cancers and is clinically associated with metastasis. This study investigates the potential associations of RECK single-nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC) susceptibility and its clinicopathologic characteristics. Methodology/Principal Findings: A total of 135 HCC cancer patients and 501 cancer-free controls were analyzed for four RECK SNPs (rs10814325, rs16932912, rs11788747, and rs10972727) using real-time PCR and PCR-RFLP genotyping analysis. After adjusting for other co-variants, the individuals carrying RECK promoter rs10814325 inheriting at least one C allele had a 1.85-fold [95% confidence interval (CI), 1.03-3.36] risk of developing HCC compared to TT wild type carriers. The HCC patients, who carried rs11788747 with at least one G allele, had a higher distant metastasis risk than wild type probands. Conclusions: RECK gene polymorphisms might be a risk factor increasing HCC susceptibility and distant metastasis in Taiwan.

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