Effect of physostigmine on the loss of consciousness induced by midazolam, etomidate and althesin.

S. T. Ho, C. S. Wong, O. Y. Hu, Y. Wang, M. H. Yen, W. Ho

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1 引文 斯高帕斯(Scopus)

摘要

The effect of physostigmine, a cholinesterase inhibitor, on the loss of consciousness induced by three different intravenous induction anesthetics, namely midazolam, etomidate and althesin at ED50, was studied in three comparable groups of patients. Ten min before induction, the first and second groups received physostigmine 8 micrograms/kg and 16 micrograms/kg, respectively, and the third group received 2 ml of saline solution. Physostigmine 16 micrograms/kg resulted in a significant decrease in the percentage of unconscious patients with midazolam (from 50% to 10%), but it did not modify the incidence with etomidate or althesin. Physostigmine at doses of 8 micrograms/kg and 16 micrograms/kg could cause 6.7% and 10% nausea, respectively. Although the mechanism of the drug interaction of physostigmine and midazolam is unclear, physostigmine could be used clinically to reverse post-anesthetic somnolence induced by midazolam.
原文英語
頁(從 - 到)643-647
頁數5
期刊Acta Anaesthesiologica Sinica
29
發行號3
出版狀態已發佈 - 九月 1 1991
對外發佈

ASJC Scopus subject areas

  • 麻醉與疼痛醫學

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