Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Yves S.Y. Hsieh, Deni Taleski, Brendan L. Wilkinson, Lakshmi C. Wijeyewickrem, Ty E. Adams, Robert N. Pike, Richard J. Payne

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

摘要

Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

原文英語
頁(從 - 到)1547-1549
頁數3
期刊Chemical Communications
48
發行號10
DOIs
出版狀態已發佈 - 一月 11 2012
對外發佈Yes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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