Effect of non-steroidal anti-inflammatory drugs on gastric and duodenal prostaglandin concentrations in patients with Helicobacter pylori infection

Guan Ying Tseng, Hwai Jeng Lin, Hsiao Yi Lin, Chin Lin Perng, Fa Yauh Lee, Wen Ching Lo, Shyh Haw Tsay, Anna Senfen Yau Li, Full Young Chang, Shou Dong Lee

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

摘要

BACKGROUND/AIMS: Both Helicobacter pylori and non-steroidal anti-inflammatory drugs are reported to affect gastroduodenal prostaglandin synthesis. However, their influence on gastric mucosal prostaglandins remains unclear. The aim of this study was to investigate the influence of non-steroidal anti-inflammatory drugs on mucosal prostaglandin synthesis in patients with Helicobacter pylori infection. METHODOLOGY: We enrolled 87 Helicobacter pylori-infected patients in this study (gastric ulcer: 33, duodenal ulcer: 41, and non-ulcer dyspepsia: 13). Of them, 27 patients received non-steroidal anti-inflammatory drugs. Endoscopy was performed and biospy specimens from gastric body, antrum and duodenal bulb were assessed for Helicobacter pylori and prostaglandin concentration. RESULTS: A significantly lower mucosal prostaglandin E2 level at gastric body (142.2 ± 28.1 ng/mg vs. 222.0 ± 12.4 ng/mg, mean ± SEM) and antrum (131.3 ± 26.4 ng/mg vs. 226.0 ± 19.0 ng/mg) was noted in Helicobacter pylori-infected gastric ulcer patients with non-steroidal anti-inflammatory drugs ingestion than in that of patients without non-steroidal anti-inflammatory drugs ingestion (p <0.05). Using a multivariate analysis, we found that non-steroidal anti-inflammatory drug was an independent variable affecting gastric and duodenal mucosal prostaglandin E3 synthesis in patients with Helicobacter pylori-infected gastric ulcer. CONCLUSIONS: Non-steroidal anti-inflammatory drugs decrease gastroduodenal mucosal prostaglandin E2 synthesis in gastric ulcer patients with Helicobacter pylori infection.

原文英語
頁(從 - 到)1000-1004
頁數5
期刊Hepato-Gastroenterology
46
發行號26
出版狀態已發佈 - 1999
對外發佈Yes

ASJC Scopus subject areas

  • Gastroenterology

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  • 引用此

    Tseng, G. Y., Lin, H. J., Lin, H. Y., Perng, C. L., Lee, F. Y., Lo, W. C., Tsay, S. H., Li, A. S. Y., Chang, F. Y., & Lee, S. D. (1999). Effect of non-steroidal anti-inflammatory drugs on gastric and duodenal prostaglandin concentrations in patients with Helicobacter pylori infection. Hepato-Gastroenterology, 46(26), 1000-1004.