Effect of metformin on the incidence of head and neck cancer in diabetics

Yung Chang Yen, Charlene Lin, Shih Wei Lin, Yong-Song Lin, Shih Feng Weng

研究成果: 雜誌貢獻文章同行評審

33 引文 斯高帕斯(Scopus)

摘要

Background The purpose of this study was to examine the effect of metformin on head and neck cancer in patients with diabetes. Methods We compared 66,600 patients, all with diabetes and all newly diagnosed with head and neck cancer in 2002. Half were being treated with metformin for diabetes (Met+) and half were not (Met-: controls). All were matched for comorbidities (obesity, coronary artery disease, hyperlipidemia, and hypertension), sex, and age. The risk of head and neck cancer at the end of 2011 was determined. Results The incidence of head and neck cancer was 34% lower in the Met+ cohort than in the Met- cohort (adjusted hazard ratio [HR] = 0.66; 95% confidence interval [CI] = 0.55-0.79). The risks for oropharyngeal cancer (adjusted HR = 0.66; 95% CI = 0.17-0.74) and nasopharyngeal carcinoma (NPC; adjusted HR = 0.50; 95% CI = 0.31-0.80) were significantly lower in the Met+ cohort than in the Met- cohort. Conclusion Metformin is associated with a lower risk of developing head and neck cancer in patients with diabetes.
原文英語
頁(從 - 到)1268-1273
頁數6
期刊Head and Neck
37
發行號9
DOIs
出版狀態已發佈 - 9月 1 2015

ASJC Scopus subject areas

  • 耳鼻咽喉科
  • 醫藥 (全部)

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