Effect of mammographic service screening on stage at presentation of breast cancers in Sweden

Stephen W. Duffy, László Tabár, Tony H H Chen, Robert A. Smith, Lars Holmberg, Håkan Jonsson, Per Lenner, Lennarth Nyström, Sven Törnberg, Jan Frisell, Amy M F Yen, Li Sheng Chen, Yueh Hsiah Chiu, Chia Yuan Wu, Hui Min Wu, Chih Chung Huang, Jane Warwick, Levent Kemetli, Patrick Chou, Gunilla SvaneEdward Azavedo, Helen Grundström, Per Sundén, Karin Leifland, Kerstin Moberg, Tor Sahlstedt, Pal Bordás, Leena Starck, Stina Carlson, Håkan Laaksonen, Shahin Abdsaleh, Erik Thurfjell, Birgitta Epstein, Maria Tholin, Ewa Frodis, Ann Sundbom, Mika Wiege, Anders Åkerlund, Bengt Lundgren

研究成果: 雜誌貢獻文章同行評審

56 引文 斯高帕斯(Scopus)

摘要

BACKGROUND. Previous results have shown a reduction in mortality with service screening in Sweden on the order of 40%. If the rate of tumors at a later stage were similarly reduced, this would give further support to the mortality findings. METHODS. The rates of lymph node-positive cancers, of tumors >2 cm in pathological size, and of tumors of TNM stage II or worse before and after the introduction of screening were compared in 13 areas in Sweden, adjusted for changes in overall incidence during the period of study and stratified by age (40-49 and 50-69 years). RESULTS. Data were obtained on a total of 23,092 cancers and 10,177,113 person-years of observation. In women exposed to screening in the screening epoch, there was a significant 45% reduction in tumors of size >2 cm compared with the prescreening (relative risk [RR] = 0.55, 95% confidence interval [CI]: 0.46-0.66) in the 40-49 age group, and a 33% reduction in the 50-69 group (RR = 0.67, 95% CI: 0.62-0.72). For lymph node-positive and stage II+ disease, there were smaller but still significant reductions. No reduction in incidence in later-stage disease was observed in the unexposed women in the screening epoch. CONCLUSIONS. Screening has significantly and substantially reduced the rates of larger tumors and lymph node-positive breast cancer in Sweden, and the magnitude of the reduction is consistent with the reduction in breast cancer mortality.
原文英語
頁(從 - 到)2205-2212
頁數8
期刊Cancer
109
發行號11
DOIs
出版狀態已發佈 - 六月 1 2007
對外發佈Yes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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