Effect of intravenous N-acetylcysteine on plasma total homocysteine and inflammatory cytokines during high flux hemodialysis

Jen Pi Tsai, Fwu Lin Yang, Chih Hsien Wang, Te Chao Fang, Ru Ping Lee, Bang Gee Hsu

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Objective: Hyperhomocysteinemia and increased inflammatory cytokines are independent risk factors in patients with renal diseases. N-acetylcysteine (NAC) is an antioxidant that is known to decrease inflammatory cytokines and plasma total homocysteine (tHcy). Therefore, the aim of this study was to compare normal saline injection with and without intravenous NAC during hemodialysis (HD) in terms of changes in serum levels of tumor necrosis factor-α (TNF-α, interleukin-10 (IL-10), high-sensitivity C-reactive protein (hs-CRP) and plasma tHcy. Patients and Methods: In total, 43 high flux HD patients were enrolled at a 4-hour HD session and split into two groups, NAC (n = 22) and NS (n = 21) treatment groups, which received either a normal saline injection with intravenous NAC or without intravenous NAC, respectively. The NS group was divided into two subgroups, one with residual renal function (n = 5) and the other with anuria (n 16). The NAC group was also divided into two subgroups, one with residual renal function (n 6) and the other with anuria (n = 16). Serum TNF-α, IL-10, hs-CRP and tHcy were measured before and immediately after HD. Results: There were no significant differences in baseline characteristics, TNF-α, IL-10, hs-CRP, and tHcy levels in intra- and intergroup comparisons. Compared to pre-HD baseline values, plasma tHcy level was lower after HD in the NS group (p

原文英語
頁(從 - 到)90-95
頁數6
期刊Tzu Chi Medical Journal
22
發行號2
DOIs
出版狀態已發佈 - 六月 2010
對外發佈Yes

指紋

Acetylcysteine
Homocysteine
Renal Dialysis
Cytokines
Interleukin-10
C-Reactive Protein
Anuria
Kidney
Hyperhomocysteinemia
Serum
Intravenous Injections
Tumor Necrosis Factor-alpha
Antioxidants
Injections

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Effect of intravenous N-acetylcysteine on plasma total homocysteine and inflammatory cytokines during high flux hemodialysis. / Tsai, Jen Pi; Yang, Fwu Lin; Wang, Chih Hsien; Fang, Te Chao; Lee, Ru Ping; Hsu, Bang Gee.

於: Tzu Chi Medical Journal, 卷 22, 編號 2, 06.2010, p. 90-95.

研究成果: 雜誌貢獻文章

Tsai, Jen Pi ; Yang, Fwu Lin ; Wang, Chih Hsien ; Fang, Te Chao ; Lee, Ru Ping ; Hsu, Bang Gee. / Effect of intravenous N-acetylcysteine on plasma total homocysteine and inflammatory cytokines during high flux hemodialysis. 於: Tzu Chi Medical Journal. 2010 ; 卷 22, 編號 2. 頁 90-95.
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abstract = "Objective: Hyperhomocysteinemia and increased inflammatory cytokines are independent risk factors in patients with renal diseases. N-acetylcysteine (NAC) is an antioxidant that is known to decrease inflammatory cytokines and plasma total homocysteine (tHcy). Therefore, the aim of this study was to compare normal saline injection with and without intravenous NAC during hemodialysis (HD) in terms of changes in serum levels of tumor necrosis factor-α (TNF-α, interleukin-10 (IL-10), high-sensitivity C-reactive protein (hs-CRP) and plasma tHcy. Patients and Methods: In total, 43 high flux HD patients were enrolled at a 4-hour HD session and split into two groups, NAC (n = 22) and NS (n = 21) treatment groups, which received either a normal saline injection with intravenous NAC or without intravenous NAC, respectively. The NS group was divided into two subgroups, one with residual renal function (n = 5) and the other with anuria (n 16). The NAC group was also divided into two subgroups, one with residual renal function (n 6) and the other with anuria (n = 16). Serum TNF-α, IL-10, hs-CRP and tHcy were measured before and immediately after HD. Results: There were no significant differences in baseline characteristics, TNF-α, IL-10, hs-CRP, and tHcy levels in intra- and intergroup comparisons. Compared to pre-HD baseline values, plasma tHcy level was lower after HD in the NS group (p",
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T1 - Effect of intravenous N-acetylcysteine on plasma total homocysteine and inflammatory cytokines during high flux hemodialysis

AU - Tsai, Jen Pi

AU - Yang, Fwu Lin

AU - Wang, Chih Hsien

AU - Fang, Te Chao

AU - Lee, Ru Ping

AU - Hsu, Bang Gee

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N2 - Objective: Hyperhomocysteinemia and increased inflammatory cytokines are independent risk factors in patients with renal diseases. N-acetylcysteine (NAC) is an antioxidant that is known to decrease inflammatory cytokines and plasma total homocysteine (tHcy). Therefore, the aim of this study was to compare normal saline injection with and without intravenous NAC during hemodialysis (HD) in terms of changes in serum levels of tumor necrosis factor-α (TNF-α, interleukin-10 (IL-10), high-sensitivity C-reactive protein (hs-CRP) and plasma tHcy. Patients and Methods: In total, 43 high flux HD patients were enrolled at a 4-hour HD session and split into two groups, NAC (n = 22) and NS (n = 21) treatment groups, which received either a normal saline injection with intravenous NAC or without intravenous NAC, respectively. The NS group was divided into two subgroups, one with residual renal function (n = 5) and the other with anuria (n 16). The NAC group was also divided into two subgroups, one with residual renal function (n 6) and the other with anuria (n = 16). Serum TNF-α, IL-10, hs-CRP and tHcy were measured before and immediately after HD. Results: There were no significant differences in baseline characteristics, TNF-α, IL-10, hs-CRP, and tHcy levels in intra- and intergroup comparisons. Compared to pre-HD baseline values, plasma tHcy level was lower after HD in the NS group (p

AB - Objective: Hyperhomocysteinemia and increased inflammatory cytokines are independent risk factors in patients with renal diseases. N-acetylcysteine (NAC) is an antioxidant that is known to decrease inflammatory cytokines and plasma total homocysteine (tHcy). Therefore, the aim of this study was to compare normal saline injection with and without intravenous NAC during hemodialysis (HD) in terms of changes in serum levels of tumor necrosis factor-α (TNF-α, interleukin-10 (IL-10), high-sensitivity C-reactive protein (hs-CRP) and plasma tHcy. Patients and Methods: In total, 43 high flux HD patients were enrolled at a 4-hour HD session and split into two groups, NAC (n = 22) and NS (n = 21) treatment groups, which received either a normal saline injection with intravenous NAC or without intravenous NAC, respectively. The NS group was divided into two subgroups, one with residual renal function (n = 5) and the other with anuria (n 16). The NAC group was also divided into two subgroups, one with residual renal function (n 6) and the other with anuria (n = 16). Serum TNF-α, IL-10, hs-CRP and tHcy were measured before and immediately after HD. Results: There were no significant differences in baseline characteristics, TNF-α, IL-10, hs-CRP, and tHcy levels in intra- and intergroup comparisons. Compared to pre-HD baseline values, plasma tHcy level was lower after HD in the NS group (p

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