摘要

Calcium phosphate ceramics used in dentistry and orthopedics are some of the most valuable biomaterials, owing to their excellent osteoconduction, osteoinduction, and osseointegration. Osteoconduction and osteoinduction are critical targets for bone regeneration, and osseointegration is essential for any dental implantations. In this study, a hydroxyapatite (HAp) hybrid coating layer with the sequential release of bone morphogenetic protein 2 (BMP-2) was deposited onto an etched titanium substrate by electrochemical deposition. The resulting release of BMP-2 from Ti-HAp was assessed by immersing samples in a simulated buffer fluid solution. Through coculture, human osteosarcoma cell proliferation and alkaline phosphatase activity were assessed. The characteristics and effect on cell proliferation of the hybrid coatings were investigated for their functionality through X-ray diffraction (XRD) and cell proliferation assays. Findings revealed that -0.8 V vs. Ag/AgCl (3 M KCl) exhibited the optimal HAp properties and a successfully coated HAp layer. XRD confirmed the crystallinity of the deposited HAp on the titanium surface. Ti-0.8 V Ti-HAp co-coating BMP sample exhibited the highest cell proliferation efficiency and was more favorable for cell growth. A successful biocompatible hybrid coating with optimized redox voltage enhanced the osseointegration process. The findings suggest that this technique could have promising clinical applications to enhance the healing times and success rates of dental implantation.
原文英語
文章編號1897
期刊Materials
11
發行號10
DOIs
出版狀態已發佈 - 十月 4 2018

指紋

Bone Morphogenetic Protein 2
Durapatite
Titanium
Hydroxyapatite
Bone
Cell proliferation
Proteins
Coatings
Dentistry
X ray diffraction
Phosphatases
Orthopedics
Calcium phosphate
Cell growth
Biocompatible Materials
Biomaterials
Alkaline Phosphatase
Assays
Buffers
Fluids

ASJC Scopus subject areas

  • Materials Science(all)

引用此文

Effect of hydroxyapatite formation on titanium surface with bone morphogenetic protein-2 loading through electrochemical deposition on MG-63 cells. / Huang, Huei Yu; Manga, Yankuba B.; Huang, Wan Ning; Lin, Chung Kwei; Tseng, Ching Li; Huang, Haw Ming; Wu, Chia Yu; Wu, Chi Chang.

於: Materials, 卷 11, 編號 10, 1897, 04.10.2018.

研究成果: 雜誌貢獻文章

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