Effect of human immunodeficiency virus type 1 transframe protein p6* mutations on viral protease-mediated Gag processing

Hsu Chen Chiu, Fu Der Wang, Yi Ming Arthur Chen, Chin Tien Wang

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)

摘要

The proteolytic processing of human immunodeficiency virus (HIV) particles mediated by the viral pol-encoded protease (PR) is essential for viral infectivity. The pol coding sequence partially overlaps with the gag coding sequence and is translated as a Gag-Pol polyprotein precursor. Within Gag-Pol, the C-terminal p6gag domain is replaced by a transframe peptide referred to as p6*, which separates the Gag nucleocapsid domain from PR. Several previous in vitro studies have ascribed a PR-suppression regulatory function to p6*. Here, it was demonstrated that an HIV-1 Gag-Pol lacking p6* is efficiently incorporated into virions when coexpressed with HIV-1 Gag precursor. However, the released virions are not processed appropriately and show a greatly reduced viral infectivity. This suggests that the p6* is indispensable during the process of PR-mediated virus particle maturation.
原文英語
頁(從 - 到)2041-2046
頁數6
期刊Journal of General Virology
87
發行號7
DOIs
出版狀態已發佈 - 七月 1 2006
對外發佈

ASJC Scopus subject areas

  • 病毒學

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