Effect of emodin on cooked-food mutagen activation

H. Lee, S. J. Tsai

研究成果: 雜誌貢獻文章同行評審

37 引文 斯高帕斯(Scopus)

摘要

The herbs Rheum palmatum B and Polygonum cuspidatum S are frequently used as laxatives and anticancer drugs in Chinese medicine. The antimutagenic activity of these herbs as well as their active component emodin was examined in Salmonella typhimurium TA98. The crude extracts and emodin induced a dose-dependent decrease in the mutagenicity of benzo[a]pyrene (B[a]P), 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2). Furthermore, emodin reduced the mutagenicity of IQ by direct inhibition of the hepatic microsomal activation and not by interaction with proximate metabolites of IQ and/or by modification of DNA repair processes in the bacterial cell.
原文英語
頁(從 - 到)765-770
頁數6
期刊Food and Chemical Toxicology
29
發行號11
DOIs
出版狀態已發佈 - 1991
對外發佈

ASJC Scopus subject areas

  • 食品科學
  • 毒理學

指紋

深入研究「Effect of emodin on cooked-food mutagen activation」主題。共同形成了獨特的指紋。

引用此