Effect of "Dang-Qui-Shao-Yao-San" a Chinese medicinal prescription for dysmenorrhea on uterus contractility in vitro

C. S. Hsu, J. Kay Yang, L. L. Yang

研究成果: 雜誌貢獻文章同行評審

31 引文 斯高帕斯(Scopus)

摘要

Dysmenorrhea is directly related to elevated level of prostaglandin F 2α (PGF2α), and is treated with nonsteroid anti-inflammatory drugs. Though efficacy of the latter is rapid, the effect is temporary, and they cause many side effects to the liver, kidney and digestive system. Because of this, Chinese medicinal therapy is being considered as a feasible alternative medicine. In this study, Dang-Qui-Shao-Yao-San (DQSYS), one of Chinese medicinal prescriptions was selected. A 50% alcohol solution was used to extract the active ingredients and create a freeze-dried product. Using rat uterine smooth muscle in vitro, DQSYS was used to suppress spontaneous contractions and PGF2α induced contractions. Then acetylcholine, ergonovine, propranolol, oxytocin and KCl were used to analyze the physiological mechanisms. The results show that DQSYS has the antagonistic action on both PGF2α and Ach induced uterine contraction. Furthermore, it has the antagonistic effect on contraction caused by KCl-depolarization. These actions may be the major mechanism of the beneficial effect of Chinese prescription in treating dysmenorrhea.
原文英語
頁(從 - 到)94-100
頁數7
期刊Phytomedicine
13
發行號1-2
DOIs
出版狀態已發佈 - 1月 5 2006

ASJC Scopus subject areas

  • 植物科學
  • 藥物發現
  • 有機化學
  • 藥理

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