摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 905-921 |
| 頁數 | 17 |
| 期刊 | Nutrients |
| 卷 | 7 |
| 發行號 | 2 |
| DOIs | |
| 出版狀態 | 已發佈 - 一月 30 2015 |
指紋
ASJC Scopus subject areas
- Food Science
引用此文
Effect of curcumin supplementation on physiological fatigue and physical performance in mice. / Huang, Wen Ching; Chiu, Wan Chun; Chuang, Hsiao Li; Tang, Deh Wei; Lee, Zon Min; Li, Wei; Chen, Fu An; Huang, Chi Chang.
於: Nutrients, 卷 7, 編號 2, 30.01.2015, p. 905-921.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Effect of curcumin supplementation on physiological fatigue and physical performance in mice
AU - Huang, Wen Ching
AU - Chiu, Wan Chun
AU - Chuang, Hsiao Li
AU - Tang, Deh Wei
AU - Lee, Zon Min
AU - Li, Wei
AU - Chen, Fu An
AU - Huang, Chi Chang
PY - 2015/1/30
Y1 - 2015/1/30
N2 - Curcumin (CCM) is a well-known phytocompound and food component found in the spice turmeric and has multifunctional bioactivities. However, few studies have examined its effects on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of CCM supplementation on fatigue and ergogenic function following physical challenge in mice. Male ICR mice were divided into four groups to receive vehicle or CCM (180 μg/mL) by oral gavage at 0, 12.3, 24.6, or 61.5 mL/kg/day for four weeks. Exercise performance and anti-fatigue function were evaluated after physical challenge by forelimb grip strength, exhaustive swimming time, and levels of physical fatigue-associated biomarkers serum lactate, ammonia, blood urea nitrogen (BUN), and glucose and tissue damage markers such as aspartate transaminase (AST), alanine transaminase (ALT), and creatine kinase (CK). CCM supplementation dose-dependently increased grip strength and endurance performance and significantly decreased lactate, ammonia, BUN, AST, ALT, and CK levels after physical challenge. Muscular glycogen content, an important energy source for exercise, was significantly increased. CCM supplementation had few subchronic toxic effects. CCM supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue.
AB - Curcumin (CCM) is a well-known phytocompound and food component found in the spice turmeric and has multifunctional bioactivities. However, few studies have examined its effects on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of CCM supplementation on fatigue and ergogenic function following physical challenge in mice. Male ICR mice were divided into four groups to receive vehicle or CCM (180 μg/mL) by oral gavage at 0, 12.3, 24.6, or 61.5 mL/kg/day for four weeks. Exercise performance and anti-fatigue function were evaluated after physical challenge by forelimb grip strength, exhaustive swimming time, and levels of physical fatigue-associated biomarkers serum lactate, ammonia, blood urea nitrogen (BUN), and glucose and tissue damage markers such as aspartate transaminase (AST), alanine transaminase (ALT), and creatine kinase (CK). CCM supplementation dose-dependently increased grip strength and endurance performance and significantly decreased lactate, ammonia, BUN, AST, ALT, and CK levels after physical challenge. Muscular glycogen content, an important energy source for exercise, was significantly increased. CCM supplementation had few subchronic toxic effects. CCM supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue.
KW - Ammonia
KW - Anti-fatigue
KW - Blood urea nitrogen
KW - Creatine kinase
KW - Endurance
KW - Forelimb grip strength
KW - Lactate
UR - http://www.scopus.com/inward/record.url?scp=84961291322&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84961291322&partnerID=8YFLogxK
U2 - 10.3390/nu7020905
DO - 10.3390/nu7020905
M3 - Article
C2 - 25647661
AN - SCOPUS:84961291322
VL - 7
SP - 905
EP - 921
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 2
ER -