Effect of commercially available green and black tea beverages on drug-metabolizing enzymes and oxidative stress in Wistar rats

Hsien Tsung Yao, Ya Ru Hsu, Chong Kuei Lii, Ai Hsuan Lin, Keng Hao Chang, Hui Ting Yang

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14 引文 斯高帕斯(Scopus)

摘要

The effect of commercially available green tea (GT) and black tea (BT) drinks on drugmetabolizing enzymes (DME) and oxidative stress in rats was investigated. Male Wistar rats were fed a laboratory chow diet and GT or BT drink for 5. weeks. Control rats received de-ionized water instead of the tea drinks. Rats received the GT and BT drinks treatment for 5. weeks showed a significant increase in hepatic microsomal cytochrome P450 (CYP) 1A1 and CYP1A2, and a significant decrease in CYP2C, CYP2E1 and CYP3A enzyme activities. Results of immunoblot analyses of enzyme protein contents showed the same trend with enzyme activity. Significant increase in UDP-glucuronosyltransferase activity and reduced glutathione content in liver and lungs were observed in rats treated with both tea drinks. A lower lipid peroxide level in lungs was observed in rats treated with GT drink. Electrophoretic mobility shift assay revealed that both tea drinks decreased pregnane X receptor binding to DNA and increased nuclear factor-erythroid 2 p45-related factor 2 binding to DNA. These results suggest that feeding of both tea drinks to rats modulated DME activities and reduced oxidative stress in liver and lungs. GT drink is more effective on reducing oxidative stress than BT drink.
原文英語
頁(從 - 到)120-127
頁數8
期刊Food and Chemical Toxicology
70
DOIs
出版狀態已發佈 - 一月 1 2014
對外發佈

ASJC Scopus subject areas

  • 食品科學
  • 毒理學

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