Effect of collagen on the mechanical properties of hydroxyapatite coatings

Keng Liang Ou, Ren Jei Chung, Fu Yi Tsai, Pei Yu Liang, Shih Wei Huang, Shou Yi Chang

研究成果: 雜誌貢獻文章同行評審

39 引文 斯高帕斯(Scopus)


In this study, the mechanical properties of bioactive coatings on Ti6Al4V substrates were investigated using instrumented nanoindentation. The aim was to observe the differences in the mechanical properties before and after immersion in collagen solution. The hydroxyapatite coatings were prepared through two processes: self-assembly in simulated body fluid and a hydrothermal method. Sintered hydroxyapatite disks were used as controls. The test samples were then incubated in a dilute collagen solution for 24 hours to produce composite coatings. The materials were investigated using XRD, SEM and nanoindentation. The results showed that the grain sizes of the hydroxyapatite coatings formed using two processes were 1 μm and 10 μm, respectively. The Young's modulus of the pure hydroxyapatite, the disk and the coatings, was 3.6 GPa. After collagen incubation treatment, the composites had a Young's modulus of 7.5 GPa. The results also showed that the strengthening phenomena of collagen were more obvious for homogeneous and small-grain hydroxyapatite coatings. These results suggest that there are similarities between these HAp/collagen composited and natural composite materials, such as teeth and bones.
頁(從 - 到)618-624
期刊Journal of the Mechanical Behavior of Biomedical Materials
出版狀態已發佈 - 5月 2011

ASJC Scopus subject areas

  • 生物材料
  • 生物醫學工程
  • 材料力學


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