Effect of central glucagon infusion on macronutrient selection in rats

Naoko Komenami, Fu Hsiung Su, Louise Thibault

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)


Compared were the light-dark pattern of absolute energy intake and macronutrient selection of male Wistar rats intracerebroventricularly infused with glucagon (5 ng/h) or saline for 7 days in a three-way selection of macronutrients. Glucagon infusion induced a decrease in 24 h and nocturnal energy intake, whereas no significant change in kcal intake accompanied vehicle infusion. The decrease in kcal intake was due to a suppression of nocturnal ingestion of carbohydrate. This parameter was left unaffected with central vehicle infusion. Glucagon-infused rats had a significantly lower body weight gain than those infused with vehicle. Our study supports the hypothesis of central glucagon's suppressive effect on food intake, but reveals that the latter reflects a lower disposition to eat carbohydrate during the dark phase. The present work emphasizes the role of glucagon in the circadian regulation of carbohydrate intake.

頁(從 - 到)383-388
期刊Physiology and Behavior
出版狀態已發佈 - 2月 1996

ASJC Scopus subject areas

  • 實驗與認知心理學
  • 行為神經科學


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