Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era

Fuu Jen Tsai, Chi Fung Cheng, Chih Ho Lai, Yang Chang Wu, Mao Wang Ho, Jen Hsien Wang, Ni Tien, Xiang Liu, Hsinyi Tsang, Ting Hsu Lin, Chiu Chu Liao, Shao Mei Huang, Ju Pi Li, Jung Chun Lin, Chih Chien Lin, Jin Hua Chen, Wen Miin Liang, Ying Ju Lin

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

摘要

HIV-infected patients exposed to antiretroviral therapy (ART) have an increased risk for hyperlipidemia and cardiovascular disease. We performed a longitudinal, comprehensive, and population-based study to investigate the cumulative effect of different types of ART regimens on hyperlipidemia risk in the Taiwanese HIV/ART cohort. A total of 13,370 HIV-infected patients (2,674 hyperlipidemia and 10,696 non-hyperlipidemia patients) were recruited after matching for age, gender, and the first diagnosis date of HIV infection by using the National Health Insurance Research Database in Taiwan. Hyperlipidemia risk associated with cumulative ART use, ART adherence, and their combination was assessed. The matched hyperlipidemia group had a larger number of patients using ART and a higher incidence of comorbidities, specifically, respiratory disease and diabetes. Patients with high ART dosage and dose-dependent manner adherence, respectively, demonstrated an increased risk of hyperlipidemia. For single ART regimens, patients receiving nucleoside reverse-transcriptase inhibitors (NRTI/NRTI)- containing regimen had the highest hyperlipidemia risk, followed by protease inhibitor (PI)- containing and non-NRTIwww containing regimens. For combination ART regimens, patients receiving a NRTI/NRTI + PI regimen had the highest hyperlipidemia risk. An increased cumulative drug dose was observed in patients who received the PI, NRTI/NRTI, NRTI, and NNRTI regimens in the hyperlipidemia group, when compared to the non-hyperlipidemia group. In conclusion, ART cumulative use, adherence, and regimen may affect hyperlipidemia risk among HIV-infected patients in a dose-dependent manner.

原文英語
頁(從 - 到)106369-106381
頁數13
期刊Oncotarget
8
發行號63
DOIs
出版狀態已發佈 - 2017

ASJC Scopus subject areas

  • Oncology

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    Tsai, F. J., Cheng, C. F., Lai, C. H., Wu, Y. C., Ho, M. W., Wang, J. H., Tien, N., Liu, X., Tsang, H., Lin, T. H., Liao, C. C., Huang, S. M., Li, J. P., Lin, J. C., Lin, C. C., Chen, J. H., Liang, W. M., & Lin, Y. J. (2017). Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era. Oncotarget, 8(63), 106369-106381. https://doi.org/10.18632/oncotarget.22465