Effect of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) hull extracts on testosterone release from rat leydig cells

Shih Min Hsia, Yi Wen Tseng, Shyi Wu Wang, Yueh Hsiung Kuo, Din Wen Huang, Paulus S. Wang, Wenchang Chiang

研究成果: 雜誌貢獻文章

14 引文 斯高帕斯(Scopus)

摘要

Adlay has been used as a traditional Chinese medicine for the treatment of many diseases. However, few studies have reported the effects of adlay seeds on the endocrine system. In the present study, the effects of methanol extracts of adlay hull (AHM) on testosterone synthesis were studied. Rat Leydig cells were incubated with different reagents including human chorionic gonadotropin, 8-bromo-adenosine-3′,5′-cyclic monophosphate, forskolin, A23187, progesterone and androstenedione in the presence or absence of AHM. The rat anterior pituitary (AP) gland was treated with gonadotropin-releasing hormone (GnRH) in vitro in the presence or absence of AHM, and the concentrations of luteinizing hormone (LH) in the media were measured. AHM decreased testosterone release via the inhibition of (1) the PKA and PKC signal transduction pathways, (2) 17β-HSD enzyme activity in rat Leydig cells, and (3) in vitro GnRH-induced LH secretion.

原文英語
頁(從 - 到)687-695
頁數9
期刊Phytotherapy Research
23
發行號5
DOIs
出版狀態已發佈 - 五月 2009
對外發佈Yes

ASJC Scopus subject areas

  • Pharmacology
  • Medicine(all)

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