Effect of acupuncture on aromatase inhibitor-induced arthralgia in patients with breast cancer

A meta-analysis of randomized controlled trials

Lawrence Chen, Chao Chun Lin, Tsai Wei Huang, Yi Chun Kuan, Yao Hsien Huang, Hung Chou Chen, Chun Yu Kao, Chih Ming Su, Ka Wai Tam

研究成果: 雜誌貢獻文章

14 引文 (Scopus)

摘要

Purpose Aromatase inhibitor (AI)-induced arthralgia (AIA) is a common side effect that may lead to premature discontinuation of effective hormonal therapy in patients with breast cancer. Acupuncture may relieve joint pain in patients with AIA. We conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effectiveness of acupuncture in pain relief in AIA. Methods The PubMed, Embase, Cochrane Library, and Scopus databases and the ClinicalTrials.gov registry were searched for studies published before February 2017. Individual effect sizes were standardized, and a meta-analysis was conducted to calculate the pooled effect size by using a random effect model. Pain was assessed using the Brief Pain Inventory (BPI) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 3–4, 6–8, and 12 weeks. Secondary outcomes included disability level, upper extremity function, physical performance, and quality of life. Results Five trials involving 181 patients were reviewed. Significant pain reduction was observed after 6–8 weeks of acupuncture treatment. Patients receiving acupuncture showed a significant decrease in the BPI worst pain score (weighted mean difference [WMD]: −3.81, 95% confidence interval [CI]: −5.15 to −2.47) and the WOMAC pain score (WMD: −130.77, 95% CI: −230.31 to −31.22) after 6–8 weeks of treatment. One of the 4 trials reported 18 minor adverse events in 8 patients during 398 intervention episodes. Conclusion Acupuncture is a safe and viable nonpharmacologic treatment that may relieve joint pain in patients with AIA. Additional studies involving a higher number of RCTs are warranted.
原文英語
頁(從 - 到)132-138
頁數7
期刊Breast
33
DOIs
出版狀態已發佈 - 六月 1 2017

指紋

Aromatase Inhibitors
Arthralgia
Acupuncture
Meta-Analysis
Randomized Controlled Trials
Breast Neoplasms
Pain
Acupuncture Therapy
Confidence Intervals
Equipment and Supplies
Ontario
PubMed
Upper Extremity
Osteoarthritis
Libraries
Registries
Therapeutics
Quality of Life
Databases

ASJC Scopus subject areas

  • Surgery

引用此文

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title = "Effect of acupuncture on aromatase inhibitor-induced arthralgia in patients with breast cancer: A meta-analysis of randomized controlled trials",
abstract = "Purpose Aromatase inhibitor (AI)-induced arthralgia (AIA) is a common side effect that may lead to premature discontinuation of effective hormonal therapy in patients with breast cancer. Acupuncture may relieve joint pain in patients with AIA. We conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effectiveness of acupuncture in pain relief in AIA. Methods The PubMed, Embase, Cochrane Library, and Scopus databases and the ClinicalTrials.gov registry were searched for studies published before February 2017. Individual effect sizes were standardized, and a meta-analysis was conducted to calculate the pooled effect size by using a random effect model. Pain was assessed using the Brief Pain Inventory (BPI) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 3–4, 6–8, and 12 weeks. Secondary outcomes included disability level, upper extremity function, physical performance, and quality of life. Results Five trials involving 181 patients were reviewed. Significant pain reduction was observed after 6–8 weeks of acupuncture treatment. Patients receiving acupuncture showed a significant decrease in the BPI worst pain score (weighted mean difference [WMD]: −3.81, 95{\%} confidence interval [CI]: −5.15 to −2.47) and the WOMAC pain score (WMD: −130.77, 95{\%} CI: −230.31 to −31.22) after 6–8 weeks of treatment. One of the 4 trials reported 18 minor adverse events in 8 patients during 398 intervention episodes. Conclusion Acupuncture is a safe and viable nonpharmacologic treatment that may relieve joint pain in patients with AIA. Additional studies involving a higher number of RCTs are warranted.",
keywords = "Acupuncture, Aromatase inhibitor-induced arthralgia, Breast cancer, Meta-analysis",
author = "Lawrence Chen and Lin, {Chao Chun} and Huang, {Tsai Wei} and Kuan, {Yi Chun} and Huang, {Yao Hsien} and Chen, {Hung Chou} and Kao, {Chun Yu} and Su, {Chih Ming} and Tam, {Ka Wai}",
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T2 - A meta-analysis of randomized controlled trials

AU - Chen, Lawrence

AU - Lin, Chao Chun

AU - Huang, Tsai Wei

AU - Kuan, Yi Chun

AU - Huang, Yao Hsien

AU - Chen, Hung Chou

AU - Kao, Chun Yu

AU - Su, Chih Ming

AU - Tam, Ka Wai

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Y1 - 2017/6/1

N2 - Purpose Aromatase inhibitor (AI)-induced arthralgia (AIA) is a common side effect that may lead to premature discontinuation of effective hormonal therapy in patients with breast cancer. Acupuncture may relieve joint pain in patients with AIA. We conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effectiveness of acupuncture in pain relief in AIA. Methods The PubMed, Embase, Cochrane Library, and Scopus databases and the ClinicalTrials.gov registry were searched for studies published before February 2017. Individual effect sizes were standardized, and a meta-analysis was conducted to calculate the pooled effect size by using a random effect model. Pain was assessed using the Brief Pain Inventory (BPI) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 3–4, 6–8, and 12 weeks. Secondary outcomes included disability level, upper extremity function, physical performance, and quality of life. Results Five trials involving 181 patients were reviewed. Significant pain reduction was observed after 6–8 weeks of acupuncture treatment. Patients receiving acupuncture showed a significant decrease in the BPI worst pain score (weighted mean difference [WMD]: −3.81, 95% confidence interval [CI]: −5.15 to −2.47) and the WOMAC pain score (WMD: −130.77, 95% CI: −230.31 to −31.22) after 6–8 weeks of treatment. One of the 4 trials reported 18 minor adverse events in 8 patients during 398 intervention episodes. Conclusion Acupuncture is a safe and viable nonpharmacologic treatment that may relieve joint pain in patients with AIA. Additional studies involving a higher number of RCTs are warranted.

AB - Purpose Aromatase inhibitor (AI)-induced arthralgia (AIA) is a common side effect that may lead to premature discontinuation of effective hormonal therapy in patients with breast cancer. Acupuncture may relieve joint pain in patients with AIA. We conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effectiveness of acupuncture in pain relief in AIA. Methods The PubMed, Embase, Cochrane Library, and Scopus databases and the ClinicalTrials.gov registry were searched for studies published before February 2017. Individual effect sizes were standardized, and a meta-analysis was conducted to calculate the pooled effect size by using a random effect model. Pain was assessed using the Brief Pain Inventory (BPI) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 3–4, 6–8, and 12 weeks. Secondary outcomes included disability level, upper extremity function, physical performance, and quality of life. Results Five trials involving 181 patients were reviewed. Significant pain reduction was observed after 6–8 weeks of acupuncture treatment. Patients receiving acupuncture showed a significant decrease in the BPI worst pain score (weighted mean difference [WMD]: −3.81, 95% confidence interval [CI]: −5.15 to −2.47) and the WOMAC pain score (WMD: −130.77, 95% CI: −230.31 to −31.22) after 6–8 weeks of treatment. One of the 4 trials reported 18 minor adverse events in 8 patients during 398 intervention episodes. Conclusion Acupuncture is a safe and viable nonpharmacologic treatment that may relieve joint pain in patients with AIA. Additional studies involving a higher number of RCTs are warranted.

KW - Acupuncture

KW - Aromatase inhibitor-induced arthralgia

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KW - Meta-analysis

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