Effect of acid suppression on gastric myoelectrical activity in GERD

Chien Lin Chen, Chih Hsun Yi, Terry B.J. Kuo, Cheryl C.H. Yang

研究成果: 雜誌貢獻文章

1 引文 斯高帕斯(Scopus)

摘要

Background/Aims: The study aimed to investigate whether acid suppression influences gastric myoelectrical activity in patients with reflux disease. Methodology: Twenty-eight patients with erosive esophagitis underwent electrogastrography. All patients were studied before and after esomeprazole. Subjects were divided into mild or moderate esophagitis in order to determine any variation in response related to esophagitis severity. Results: The reflux symptom improved from 4.2 at baseline to 1.0 at week 8 (P<0.001). A significant increase in postprandial gastric 3 cycle per minute (normal) activity was observed at week 8 (P<0.05). There was also significantly increased postprandial gastric 3 cycle per minute (normal) activity in moderate esophagitis (P<0.05). Conclusions: The effect of acid suppression on gastric myoelectrical activity is subtle with an enhancement in normal gastric myoelectrical activity. The myoelectrical response to acid suppression appears to be associated with esophagitis severity.
原文英語
頁(從 - 到)1353-1355
頁數3
期刊Hepato-Gastroenterology
55
發行號85
出版狀態已發佈 - 七月 2008
對外發佈Yes

ASJC Scopus subject areas

  • Medicine(all)
  • Hepatology
  • Gastroenterology

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    Chen, C. L., Yi, C. H., Kuo, T. B. J., & Yang, C. C. H. (2008). Effect of acid suppression on gastric myoelectrical activity in GERD. Hepato-Gastroenterology, 55(85), 1353-1355.