ED presentation of neutropenic enterocolitis in adult patients with acute leukemia

Teh F. Hsu, Hsien H. Huang, D. H T Yen, Wei Fong Kao, Jen D. Chen, Lee M. Wang, Chen Hsen Lee

研究成果: 雜誌貢獻文章

22 引文 (Scopus)

摘要

The purpose of this study was to investigate the initial clinical features and subsequent outcomes in patients with adult leukemia with typhlitis or neutropenic enterocolitis. A retrospective review of 10 episodes of neutropenic enterocolitis in nine patients (age range, 21-71 years) with acute leukemia from March 1, 1990, through February 28, 2002, was conducted. In clinical presentations, fever appears in all patients, followed by abdominal pain or tenderness (90%) and diarrhea (60%), respectively. In particular, three cases were coincidentally diagnosed as leukemia before any chemotherapy. The most common diagnostic modality used for the diagnosis of neutropenic enterocolitis was computed tomography (CT) scan (seven episodes). Medical treatments, including broad-spectrum antibiotics, bowel rest, and total parenteral nutrition, were applied to seven patients. Laparotomy with bowel resection was performed on two patients with bowel necrosis and severe peritonitis. Of all nine cases, six were fatal as a result of sepsis, a common complication of neutropenic enterocolitis. As the incidence of neutropenic enterocolitis increases in patients with acute leukemia, EPs should be alert and make an early diagnosis of this rapidly deteriorated and life-threatening disease.

原文英語
頁(從 - 到)276-279
頁數4
期刊American Journal of Emergency Medicine
22
發行號4
DOIs
出版狀態已發佈 - 七月 2004
對外發佈Yes

指紋

Neutropenic Enterocolitis
Leukemia
Typhlitis
Total Parenteral Nutrition
Peritonitis
Laparotomy
Abdominal Pain
Early Diagnosis
Diarrhea
Sepsis
Fever
Necrosis
Tomography
Anti-Bacterial Agents
Drug Therapy
Incidence

ASJC Scopus subject areas

  • Emergency Medicine

引用此文

Hsu, T. F., Huang, H. H., Yen, D. H. T., Kao, W. F., Chen, J. D., Wang, L. M., & Lee, C. H. (2004). ED presentation of neutropenic enterocolitis in adult patients with acute leukemia. American Journal of Emergency Medicine, 22(4), 276-279. https://doi.org/10.1016/j.ajem.2004.02.014

ED presentation of neutropenic enterocolitis in adult patients with acute leukemia. / Hsu, Teh F.; Huang, Hsien H.; Yen, D. H T; Kao, Wei Fong; Chen, Jen D.; Wang, Lee M.; Lee, Chen Hsen.

於: American Journal of Emergency Medicine, 卷 22, 編號 4, 07.2004, p. 276-279.

研究成果: 雜誌貢獻文章

Hsu, TF, Huang, HH, Yen, DHT, Kao, WF, Chen, JD, Wang, LM & Lee, CH 2004, 'ED presentation of neutropenic enterocolitis in adult patients with acute leukemia', American Journal of Emergency Medicine, 卷 22, 編號 4, 頁 276-279. https://doi.org/10.1016/j.ajem.2004.02.014
Hsu, Teh F. ; Huang, Hsien H. ; Yen, D. H T ; Kao, Wei Fong ; Chen, Jen D. ; Wang, Lee M. ; Lee, Chen Hsen. / ED presentation of neutropenic enterocolitis in adult patients with acute leukemia. 於: American Journal of Emergency Medicine. 2004 ; 卷 22, 編號 4. 頁 276-279.
@article{98d8a4fb06ae4a0482793cdb2cb718db,
title = "ED presentation of neutropenic enterocolitis in adult patients with acute leukemia",
abstract = "The purpose of this study was to investigate the initial clinical features and subsequent outcomes in patients with adult leukemia with typhlitis or neutropenic enterocolitis. A retrospective review of 10 episodes of neutropenic enterocolitis in nine patients (age range, 21-71 years) with acute leukemia from March 1, 1990, through February 28, 2002, was conducted. In clinical presentations, fever appears in all patients, followed by abdominal pain or tenderness (90{\%}) and diarrhea (60{\%}), respectively. In particular, three cases were coincidentally diagnosed as leukemia before any chemotherapy. The most common diagnostic modality used for the diagnosis of neutropenic enterocolitis was computed tomography (CT) scan (seven episodes). Medical treatments, including broad-spectrum antibiotics, bowel rest, and total parenteral nutrition, were applied to seven patients. Laparotomy with bowel resection was performed on two patients with bowel necrosis and severe peritonitis. Of all nine cases, six were fatal as a result of sepsis, a common complication of neutropenic enterocolitis. As the incidence of neutropenic enterocolitis increases in patients with acute leukemia, EPs should be alert and make an early diagnosis of this rapidly deteriorated and life-threatening disease.",
keywords = "emergency department, leukemia, Typhlitis",
author = "Hsu, {Teh F.} and Huang, {Hsien H.} and Yen, {D. H T} and Kao, {Wei Fong} and Chen, {Jen D.} and Wang, {Lee M.} and Lee, {Chen Hsen}",
year = "2004",
month = "7",
doi = "10.1016/j.ajem.2004.02.014",
language = "English",
volume = "22",
pages = "276--279",
journal = "American Journal of Emergency Medicine",
issn = "0735-6757",
publisher = "W.B. Saunders",
number = "4",

}

TY - JOUR

T1 - ED presentation of neutropenic enterocolitis in adult patients with acute leukemia

AU - Hsu, Teh F.

AU - Huang, Hsien H.

AU - Yen, D. H T

AU - Kao, Wei Fong

AU - Chen, Jen D.

AU - Wang, Lee M.

AU - Lee, Chen Hsen

PY - 2004/7

Y1 - 2004/7

N2 - The purpose of this study was to investigate the initial clinical features and subsequent outcomes in patients with adult leukemia with typhlitis or neutropenic enterocolitis. A retrospective review of 10 episodes of neutropenic enterocolitis in nine patients (age range, 21-71 years) with acute leukemia from March 1, 1990, through February 28, 2002, was conducted. In clinical presentations, fever appears in all patients, followed by abdominal pain or tenderness (90%) and diarrhea (60%), respectively. In particular, three cases were coincidentally diagnosed as leukemia before any chemotherapy. The most common diagnostic modality used for the diagnosis of neutropenic enterocolitis was computed tomography (CT) scan (seven episodes). Medical treatments, including broad-spectrum antibiotics, bowel rest, and total parenteral nutrition, were applied to seven patients. Laparotomy with bowel resection was performed on two patients with bowel necrosis and severe peritonitis. Of all nine cases, six were fatal as a result of sepsis, a common complication of neutropenic enterocolitis. As the incidence of neutropenic enterocolitis increases in patients with acute leukemia, EPs should be alert and make an early diagnosis of this rapidly deteriorated and life-threatening disease.

AB - The purpose of this study was to investigate the initial clinical features and subsequent outcomes in patients with adult leukemia with typhlitis or neutropenic enterocolitis. A retrospective review of 10 episodes of neutropenic enterocolitis in nine patients (age range, 21-71 years) with acute leukemia from March 1, 1990, through February 28, 2002, was conducted. In clinical presentations, fever appears in all patients, followed by abdominal pain or tenderness (90%) and diarrhea (60%), respectively. In particular, three cases were coincidentally diagnosed as leukemia before any chemotherapy. The most common diagnostic modality used for the diagnosis of neutropenic enterocolitis was computed tomography (CT) scan (seven episodes). Medical treatments, including broad-spectrum antibiotics, bowel rest, and total parenteral nutrition, were applied to seven patients. Laparotomy with bowel resection was performed on two patients with bowel necrosis and severe peritonitis. Of all nine cases, six were fatal as a result of sepsis, a common complication of neutropenic enterocolitis. As the incidence of neutropenic enterocolitis increases in patients with acute leukemia, EPs should be alert and make an early diagnosis of this rapidly deteriorated and life-threatening disease.

KW - emergency department

KW - leukemia

KW - Typhlitis

UR - http://www.scopus.com/inward/record.url?scp=3142671586&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3142671586&partnerID=8YFLogxK

U2 - 10.1016/j.ajem.2004.02.014

DO - 10.1016/j.ajem.2004.02.014

M3 - Article

C2 - 15258868

AN - SCOPUS:3142671586

VL - 22

SP - 276

EP - 279

JO - American Journal of Emergency Medicine

JF - American Journal of Emergency Medicine

SN - 0735-6757

IS - 4

ER -