EBV-associated Burkitt lymphoma in Taiwan is not age-related

Bo Jung Chen, Sheng Tsung Chang, Shih Feng Weng, Wan Ting Huang, Pei Yi Chu, Pin Pen Hsieh, Yun Chih Jung, Chun Chi Kuo, Yu Ting Chuang, Shih Sung Chuang

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

This study retrospectively investigated 54 cases of sporadic Burkitt lymphoma in Taiwan with histopathology review, immunohistochemistry, Epstein-Barr virus (EBV) in situ hybridization (EBER) and fluorescence in situ hybridization (FISH). The great majority revealed typical immunophenotype and 89% (47/53) cases expressed myc protein. EBER was positive in 20% (11/54) of cases, more frequently with nodal presentation, but not significantly associated with age (pediatric vs adult), abdominal vs extra-abdominal presentation or overall survival (OS). MYC and IGH were rearranged in 94% (46/49) and 85% (41/48) of cases, respectively. The concordance rate between myc expression and MYC translocation was 83% (40/48). By univariate analysis, OS was statistically associated with age, with or without chemotherapy, central nervous system (CNS) involvement, CNS prophylaxis and leukemic transformation, but not gender, nodal vs extranodal involvement, stage, immunohistochemistry, EBER, myc expression, MYC translocation or radiotherapy. By multivariate analysis, CNS involvement at presentation and administration of chemotherapy were statistically associated with OS.

原文英語
頁(從 - 到)644-653
頁數10
期刊Leukemia and Lymphoma
57
發行號3
DOIs
出版狀態已發佈 - 3月 3 2016

ASJC Scopus subject areas

  • 血液學
  • 腫瘤科
  • 癌症研究

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