Early viral entry assays for the identification and evaluation of antiviral compounds

Chen Jei Tai, Chia Lin Li, Cheng Jeng Tai, Chien Kai Wang, Liang Tzung Lin

研究成果: 雜誌貢獻文章

9 引文 (Scopus)

摘要

Cell-based systems are useful for discovering antiviral agents. Dissecting the viral life cycle, particularly the early entry stages, allows a mechanistic approach to identify and evaluate antiviral agents that target specific steps of the viral entry. In this report, the methods of examining viral inactivation, viral attachment, and viral entry/fusion as antiviral assays for such purposes are described, using hepatitis C virus as a model. These assays should be useful for discovering novel antagonists/inhibitors to early viral entry and help expand the scope of candidate antiviral agents for further drug development.

原文英語
文章編號e53124
期刊Journal of Visualized Experiments
2015
發行號104
DOIs
出版狀態已發佈 - 十月 29 2015

指紋

Antiviral agents
Antiviral Agents
Assays
Virus Inactivation
Viruses
Life cycle
Fusion reactions
Life Cycle Stages
Hepacivirus
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemical Engineering(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

引用此文

Early viral entry assays for the identification and evaluation of antiviral compounds. / Tai, Chen Jei; Li, Chia Lin; Tai, Cheng Jeng; Wang, Chien Kai; Lin, Liang Tzung.

於: Journal of Visualized Experiments, 卷 2015, 編號 104, e53124, 29.10.2015.

研究成果: 雜誌貢獻文章

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