Early recovery of interhemispheric functional connectivity after corpus callosotomy

Sheng Che Hung, Cheng Chia Lee, Hsin Hung Chen, Chien Chen, Hsiu Mei Wu, Ching Po Lin, Syu Jyun Peng

研究成果: 雜誌貢獻文章同行評審

14 引文 斯高帕斯(Scopus)


Objective: To investigate whether interhemispheric functional connectivity (FC) recovers in the first year after total callosotomy. Methods: Eight epilepsy patients undergoing total callosotomy were recruited. Resting-state functional magnetic resonance imaging was acquired before and after surgery. The precallosotomy and postcallosotomy interhemispheric and intrahemispheric FC was analyzed by using graph theory and voxel-mirrored homotopic connectivity (VMHC). The seizure outcome was scored using the Engel surgical outcome scale. Results: After callosotomy (mean postoperative interval = 4 months), the network density, average node degree, characteristic path length, and global efficiency of the whole interhemispheric networks were significantly decreased, compared to those in the precallosotomy networks. However, postcallosotomy interhemispheric FC and homotopic VMHC were not significantly reduced in bilateral frontal and temporal lobes. The network density and average node degree of the intrahemispheric networks were significantly increased. The characteristic path length and global efficiency of intrahemispheric networks were unchanged. Significance: The interhemispheric FC may be preserved or recover early within the first postoperative year after total callosotomy, particularly in the frontal and anterior temporal lobes.
頁(從 - 到)1126-1136
出版狀態已發佈 - 1月 1 2019

ASJC Scopus subject areas

  • 神經內科
  • 神經病學(臨床)


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