Early idiopathic normal pressure hydrocephalus patients with neuropsychological impairment are associated with increased fractional anisotropy in the anterior thalamic nucleus

Yung Chieh Chen, Shih Wei Chiang, Chia Hsing Chi, Michelle Liou, Duen Pang Kuo, Hung Wen Kao, Hsiao Wen Chung, Hsin I. Ma, Giia Sheun Peng, Yu Te Wu, Cheng Yu Chen

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

In this study, we aimed to investigate the reactive changes in diffusion tensor imaging (DTI)-derived diffusion metrics of the anterior thalamic nucleus (AN), a relaying center for the Papez circuit, in early idiopathic normal pressure hydrocephalus (iNPH) patients with memory impairment, as well as its correlation with the patients' neuropsychological performances. In total, 28 probable iNPH patients with symptom onset within 1 year and 17 control subjects were prospectively recruited between 2010 and 2013 for this institutional review board-approved study. Imaging studies including DTI and a neuropsychological assessment battery were performed in all subjects. Diffusion metrics were measured from the region of the AN using tract-deterministic seeding method by reconstructing the mammillo-thalamo-cingulate connections within the Papez circuit. Differences in diffusion metrics and memory assessment scores between the patient and control group were examined via the Mann-Whitney U test. Spearman correlation analyses were performed to examine associations between diffusion metrics of AN and neuropsychological tests within the patient group. We discovered that early iNPH patients exhibited marked elevations in fractional anisotropy, pure diffusion anisotropy, and axial diffusivity (all P
原文英語
文章編號e3636
期刊Medicine (United States)
95
發行號19
DOIs
出版狀態已發佈 - 2016

ASJC Scopus subject areas

  • Medicine(all)

指紋 深入研究「Early idiopathic normal pressure hydrocephalus patients with neuropsychological impairment are associated with increased fractional anisotropy in the anterior thalamic nucleus」主題。共同形成了獨特的指紋。

引用此