摘要

Depression is one of the frequent complications following a mild traumatic brain injury (mTBI). Recent research indicated that abnormalities in the autonomic nervous system (ANS) can be evaluated by a noninvasive power spectral analysis of the heart rate variability (HRV). In this study, we investigated whether a frequency-domain analysis of HRV was correlated with late depression in mTBI patients. In total, 181 patients diagnosed with mTBI and 83 volunteers as healthy controls were recruited in 2010-2014. Beck Depression Inventory (BDI) scores were used to evaluate depression in the 1st week of assessment and at 1.5-, 3-, 6-, 12-, and 18-month follow-ups. Correlation and logistic regression analyses of the 1st week HRV parameters with BDI scores at 18 months were performed in individual female mTBI patients. Female mTBI patients were more vulnerable to depression accompanied by reduced HRV compared to healthy controls. Over time, depression was aggravated in female mTBI patients but was alleviated in male mTBI patients. A significantly lower parasympathetic proportion of the ANS was noted at 18 months with respect to the 1st week in female mTBI patients. In addition, depression in female mTBI patients at 18 months after injury was significantly correlated with a decrease in the parasympathetic proportion of the ANS in the 1st week (ρ=-0.411; p < .05). Dysautonomia resulted in higher risks of depression in female mTBI patients. We concluded that early dysautonomia following an mTBI contributes to late depression in female mTBI patients.
原文英語
頁(從 - 到)455-464
期刊Psychophysiology
53
發行號4
DOIs
出版狀態已發佈 - 四月 1 2016

指紋

Brain Concussion
Primary Dysautonomias
Heart Rate
Autonomic Nervous System
Traumatic Brain Injury
Equipment and Supplies

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Experimental and Cognitive Psychology
  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

引用此文

Early dysautonomia detected by heart rate variability predicts late depression in female patients following mild traumatic brain injury. / Sung, Chih Wei; Lee, Hsin-Chien; Chiang, Yung-Hsiao; Chiu, Wen-Ta; Chu, Shu Fen; Ou, Ju Chi; Tsai, Shin-Han; Liao, Kuo Hsing; Lin, Chien-Min; Lin, Jia-Wei; Chen, Gunng Shinng; Li, Wei Jiun; Wang, Jia-Yi.

於: Psychophysiology, 卷 53, 編號 4, 01.04.2016, p. 455-464.

研究成果: 雜誌貢獻文章

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title = "Early dysautonomia detected by heart rate variability predicts late depression in female patients following mild traumatic brain injury",
abstract = "Depression is one of the frequent complications following a mild traumatic brain injury (mTBI). Recent research indicated that abnormalities in the autonomic nervous system (ANS) can be evaluated by a noninvasive power spectral analysis of the heart rate variability (HRV). In this study, we investigated whether a frequency-domain analysis of HRV was correlated with late depression in mTBI patients. In total, 181 patients diagnosed with mTBI and 83 volunteers as healthy controls were recruited in 2010-2014. Beck Depression Inventory (BDI) scores were used to evaluate depression in the 1st week of assessment and at 1.5-, 3-, 6-, 12-, and 18-month follow-ups. Correlation and logistic regression analyses of the 1st week HRV parameters with BDI scores at 18 months were performed in individual female mTBI patients. Female mTBI patients were more vulnerable to depression accompanied by reduced HRV compared to healthy controls. Over time, depression was aggravated in female mTBI patients but was alleviated in male mTBI patients. A significantly lower parasympathetic proportion of the ANS was noted at 18 months with respect to the 1st week in female mTBI patients. In addition, depression in female mTBI patients at 18 months after injury was significantly correlated with a decrease in the parasympathetic proportion of the ANS in the 1st week (ρ=-0.411; p < .05). Dysautonomia resulted in higher risks of depression in female mTBI patients. We concluded that early dysautonomia following an mTBI contributes to late depression in female mTBI patients.",
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author = "Sung, {Chih Wei} and Hsin-Chien Lee and Yung-Hsiao Chiang and Wen-Ta Chiu and Chu, {Shu Fen} and Ou, {Ju Chi} and Shin-Han Tsai and Liao, {Kuo Hsing} and Chien-Min Lin and Jia-Wei Lin and Chen, {Gunng Shinng} and Li, {Wei Jiun} and Jia-Yi Wang",
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T1 - Early dysautonomia detected by heart rate variability predicts late depression in female patients following mild traumatic brain injury

AU - Sung, Chih Wei

AU - Lee, Hsin-Chien

AU - Chiang, Yung-Hsiao

AU - Chiu, Wen-Ta

AU - Chu, Shu Fen

AU - Ou, Ju Chi

AU - Tsai, Shin-Han

AU - Liao, Kuo Hsing

AU - Lin, Chien-Min

AU - Lin, Jia-Wei

AU - Chen, Gunng Shinng

AU - Li, Wei Jiun

AU - Wang, Jia-Yi

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Depression is one of the frequent complications following a mild traumatic brain injury (mTBI). Recent research indicated that abnormalities in the autonomic nervous system (ANS) can be evaluated by a noninvasive power spectral analysis of the heart rate variability (HRV). In this study, we investigated whether a frequency-domain analysis of HRV was correlated with late depression in mTBI patients. In total, 181 patients diagnosed with mTBI and 83 volunteers as healthy controls were recruited in 2010-2014. Beck Depression Inventory (BDI) scores were used to evaluate depression in the 1st week of assessment and at 1.5-, 3-, 6-, 12-, and 18-month follow-ups. Correlation and logistic regression analyses of the 1st week HRV parameters with BDI scores at 18 months were performed in individual female mTBI patients. Female mTBI patients were more vulnerable to depression accompanied by reduced HRV compared to healthy controls. Over time, depression was aggravated in female mTBI patients but was alleviated in male mTBI patients. A significantly lower parasympathetic proportion of the ANS was noted at 18 months with respect to the 1st week in female mTBI patients. In addition, depression in female mTBI patients at 18 months after injury was significantly correlated with a decrease in the parasympathetic proportion of the ANS in the 1st week (ρ=-0.411; p < .05). Dysautonomia resulted in higher risks of depression in female mTBI patients. We concluded that early dysautonomia following an mTBI contributes to late depression in female mTBI patients.

AB - Depression is one of the frequent complications following a mild traumatic brain injury (mTBI). Recent research indicated that abnormalities in the autonomic nervous system (ANS) can be evaluated by a noninvasive power spectral analysis of the heart rate variability (HRV). In this study, we investigated whether a frequency-domain analysis of HRV was correlated with late depression in mTBI patients. In total, 181 patients diagnosed with mTBI and 83 volunteers as healthy controls were recruited in 2010-2014. Beck Depression Inventory (BDI) scores were used to evaluate depression in the 1st week of assessment and at 1.5-, 3-, 6-, 12-, and 18-month follow-ups. Correlation and logistic regression analyses of the 1st week HRV parameters with BDI scores at 18 months were performed in individual female mTBI patients. Female mTBI patients were more vulnerable to depression accompanied by reduced HRV compared to healthy controls. Over time, depression was aggravated in female mTBI patients but was alleviated in male mTBI patients. A significantly lower parasympathetic proportion of the ANS was noted at 18 months with respect to the 1st week in female mTBI patients. In addition, depression in female mTBI patients at 18 months after injury was significantly correlated with a decrease in the parasympathetic proportion of the ANS in the 1st week (ρ=-0.411; p < .05). Dysautonomia resulted in higher risks of depression in female mTBI patients. We concluded that early dysautonomia following an mTBI contributes to late depression in female mTBI patients.

KW - Autonomic dysfunction

KW - Depression

KW - Dysautonomia

KW - Heart rate variability

KW - MTBI

UR - https://goo.gl/YCnVD9

UR - https://goo.gl/jk6rcM

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DO - 10.1111/psyp.12575

M3 - Article

VL - 53

SP - 455

EP - 464

JO - Psychophysiology

JF - Psychophysiology

SN - 0048-5772

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ER -