摘要
To quantitate cerebrospinal fluid (CSF) concentrations of matrix metalloproteinase 9 (MMP-9) in adult patients with Klebsiella pneumoniae meningitis and to correlate levels of MMP-9 with parameters of intrathecal inflammation and analyze the kinetic changes of MMP-9. In a prospective cohort study, levels of MMP-9 and tissue inhibitor of matrix metalloproteinase (TIMP-1) concentrations were measured in the CSF of six adult patients with meningitis and 11 controls. MMP-9 and TIMP-1 were detected in all of the six patients at presentation and follow up lumbar puncture. CSF levels of MMP-9 (6.71±7.29 ng/ml) and TIMP-1(454.3±242.9 ng/ml) were higher in patients than in the control group (0.07±0.11 ng/ml and 27.14±39.34 ng/ml, respectively). Levels of MMP-9 correlated with CSF concentrations of protein, cell count and lactate. Repeated lumbar punctures showed that levels of MMP-9 decrease during clinical recovery, although the levels of MMP-9 in the CSF are variable because of the small number of cases. The relative change in gelatin zymography is comparable to the changes of MMP-9 levels found in ELISA. MMP-9 levels in CSF may be a useful tool in follow-up in patients with K. pneumoniae meningitis.
原文 | 英語 |
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頁(從 - 到) | 247-253 |
頁數 | 7 |
期刊 | Inflammation |
卷 | 31 |
發行號 | 4 |
DOIs | |
出版狀態 | 已發佈 - 8月 2008 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 醫藥 (全部)
- 免疫學
- 細胞生物學