Duration of red blood cell storage and inflammatory marker generation

Caroline Sut, Sofiane Tariket, Ming Li Chou, Olivier Garraud, Sandrine Laradi, Hind Hamzeh-Cognasse, Jerard Seghatchian, Thierry Burnouf, Fabrice Cognasse

研究成果: 雜誌貢獻回顧型文獻

15 引文 斯高帕斯(Scopus)

摘要

Red blood cell (RBC) transfusion is a life-saving treatment for several pathologies. RBCs for transfusion are stored refrigerated in a preservative solution, which extends their shelf-life for up to 42 days. During storage, the RBCs endure abundant physicochemical changes, named RBC storage lesions, which affect the overall quality standard, the functional integrity and in vivo survival of the transfused RBCs. Some of the changes occurring in the early stages of the storage period (for approximately two weeks) are reversible but become irreversible later on as the storage is extended. In this review, we aim to decipher the duration of RBC storage and inflammatory marker generation. This phenomenon is included as one of the causes of transfusion-related immunomodulation (TRIM), an emerging concept developed to potentially elucidate numerous clinical observations that suggest that RBC transfusion is associated with increased inflammatory events or effects with clinical consequence.
原文英語
頁(從 - 到)145-152
頁數8
期刊Blood Transfusion
15
發行號2
DOIs
出版狀態已發佈 - 三月 1 2017

    指紋

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology

引用此

Sut, C., Tariket, S., Chou, M. L., Garraud, O., Laradi, S., Hamzeh-Cognasse, H., Seghatchian, J., Burnouf, T., & Cognasse, F. (2017). Duration of red blood cell storage and inflammatory marker generation. Blood Transfusion, 15(2), 145-152. https://doi.org/10.2450/2017.0343-16