Ductal adenocarcinoma of the pancreas with huge cystic degeneration: A lesion to be distinguished from pseudocyst and mucinous cystadenocarcinoma

Li yu Lee, Hui-Ling Hsu, Han Ming Chen, Chuen Hsueh

研究成果: 雜誌貢獻文章同行評審

23 引文 斯高帕斯(Scopus)

摘要

Cystic neoplasms of the pancreas are rare and often mistaken for pseudocyst by imaging studies and macroscopic examination. We describe an unusual tumor of the pancreas composed of a mural nodule of anaplastic carcinoma arising from a huge ductal adenocarcinoma undergoing cystic degeneration. The cyst measured 27 × 13 × 4 cm. Light microscopy showed that the cyst was partly lined by a single layer of cuboidal to columnar tumor cells with focal mucin production and was surrounded by hyalinized connective tissue. Most lining epithelial cells were absent owing to extensive degenerative process. Immunohistochemical studies showed positive staining of cytokeratin and vimentin for pleomorphic giant tumor cells, which were negative for leukocyte common antigen (CD45), KP-1 (CD68), epithelial membrane antigen (EMA), and carcinoembryonic antigen (CEA). The ductal adenocarcinoma stained strongly positive for cytokeratin and EMA, and negative for vimentin, CD45, CD68, and CEA. The clinical course of the current case was extremely poor and the prognosis resembled that of an anaplastic carcinoma. Therefore, we like to emphasize the importance of complete excision and extensive sampling of any cystic neoplasms in the pancreas including those with large cystic component to avoid missing the malignant elements.

原文英語
頁(從 - 到)235-239
頁數5
期刊International Journal of Surgical Pathology
11
發行號3
DOIs
出版狀態已發佈 - 一月 1 2003
對外發佈

ASJC Scopus subject areas

  • 解剖學
  • 手術
  • 病理學與法醫學

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