Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan

Jen J. Lee, Chun N. Lee, Jen Suo, I. Hsin Chiang, Chin B. Lin, Teng Y. Lin, Yeong C. Tsai

研究成果: 雜誌貢獻文章

10 引文 (Scopus)

摘要

Objective: To evaluate patterns of drug resistance of Mycobacterium tuberculosis in eastern Taiwan. Materials and Methods: Two hundred and fifty-two isolates collected from January 2001 through December 2002 were tested for drug susceptibility using the agar proportion method at Tzu Chi General Hospital. Results: The overall rate of resistance to at least one drug was 28.6%. The overall resistance rates to individual drugs were 21.8% to isoniazid, 8.3% to streptomycin, 12.7% to rifampin, and 12.7% to ethambutol. Among the 190 isolates from patients without prior treatment, 16.8% of the strains were resistant to at least one drug. Resistance to isoniazid (11.1%), ethambutol (5.8%), or streptomycin (5.3%) was more common than resistance to rifampin (2.1%). The prevalence of primary multidrug resistance was 2.1%. Among the 62 isolates from patients with histories of anti-TB treatment, the prevalence of resistance to any of the four drugs was 64.5%. The acquired resistance rates to individual drugs were 54.8% to isoniazid, 17.7% to streptomycin, 45.2% to rifampin, and 33.9% to ethambutol. Conclusions: The prevalence of drug resistance is very high in eastern Taiwan, and the surveys for anti-tuberculosis drug resistance should be repeated annually. Measures to decrease the multidrug-resistance rate are greatly needed.
原文英語
頁(從 - 到)229-234
頁數6
期刊Tzu Chi Medical Journal
15
發行號4
出版狀態已發佈 - 八月 2003

指紋

Taiwan
Mycobacterium tuberculosis
Drug Resistance
Ethambutol
Isoniazid
Streptomycin
Rifampin
Pharmaceutical Preparations
Multiple Drug Resistance
General Hospitals
Agar
Tuberculosis
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Lee, J. J., Lee, C. N., Suo, J., Chiang, I. H., Lin, C. B., Lin, T. Y., & Tsai, Y. C. (2003). Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan. Tzu Chi Medical Journal, 15(4), 229-234.

Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan. / Lee, Jen J.; Lee, Chun N.; Suo, Jen; Chiang, I. Hsin; Lin, Chin B.; Lin, Teng Y.; Tsai, Yeong C.

於: Tzu Chi Medical Journal, 卷 15, 編號 4, 08.2003, p. 229-234.

研究成果: 雜誌貢獻文章

Lee, JJ, Lee, CN, Suo, J, Chiang, IH, Lin, CB, Lin, TY & Tsai, YC 2003, 'Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan', Tzu Chi Medical Journal, 卷 15, 編號 4, 頁 229-234.
Lee JJ, Lee CN, Suo J, Chiang IH, Lin CB, Lin TY 等. Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan. Tzu Chi Medical Journal. 2003 8月;15(4):229-234.
Lee, Jen J. ; Lee, Chun N. ; Suo, Jen ; Chiang, I. Hsin ; Lin, Chin B. ; Lin, Teng Y. ; Tsai, Yeong C. / Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan. 於: Tzu Chi Medical Journal. 2003 ; 卷 15, 編號 4. 頁 229-234.
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abstract = "Objective: To evaluate patterns of drug resistance of Mycobacterium tuberculosis in eastern Taiwan. Materials and Methods: Two hundred and fifty-two isolates collected from January 2001 through December 2002 were tested for drug susceptibility using the agar proportion method at Tzu Chi General Hospital. Results: The overall rate of resistance to at least one drug was 28.6{\%}. The overall resistance rates to individual drugs were 21.8{\%} to isoniazid, 8.3{\%} to streptomycin, 12.7{\%} to rifampin, and 12.7{\%} to ethambutol. Among the 190 isolates from patients without prior treatment, 16.8{\%} of the strains were resistant to at least one drug. Resistance to isoniazid (11.1{\%}), ethambutol (5.8{\%}), or streptomycin (5.3{\%}) was more common than resistance to rifampin (2.1{\%}). The prevalence of primary multidrug resistance was 2.1{\%}. Among the 62 isolates from patients with histories of anti-TB treatment, the prevalence of resistance to any of the four drugs was 64.5{\%}. The acquired resistance rates to individual drugs were 54.8{\%} to isoniazid, 17.7{\%} to streptomycin, 45.2{\%} to rifampin, and 33.9{\%} to ethambutol. Conclusions: The prevalence of drug resistance is very high in eastern Taiwan, and the surveys for anti-tuberculosis drug resistance should be repeated annually. Measures to decrease the multidrug-resistance rate are greatly needed.",
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AB - Objective: To evaluate patterns of drug resistance of Mycobacterium tuberculosis in eastern Taiwan. Materials and Methods: Two hundred and fifty-two isolates collected from January 2001 through December 2002 were tested for drug susceptibility using the agar proportion method at Tzu Chi General Hospital. Results: The overall rate of resistance to at least one drug was 28.6%. The overall resistance rates to individual drugs were 21.8% to isoniazid, 8.3% to streptomycin, 12.7% to rifampin, and 12.7% to ethambutol. Among the 190 isolates from patients without prior treatment, 16.8% of the strains were resistant to at least one drug. Resistance to isoniazid (11.1%), ethambutol (5.8%), or streptomycin (5.3%) was more common than resistance to rifampin (2.1%). The prevalence of primary multidrug resistance was 2.1%. Among the 62 isolates from patients with histories of anti-TB treatment, the prevalence of resistance to any of the four drugs was 64.5%. The acquired resistance rates to individual drugs were 54.8% to isoniazid, 17.7% to streptomycin, 45.2% to rifampin, and 33.9% to ethambutol. Conclusions: The prevalence of drug resistance is very high in eastern Taiwan, and the surveys for anti-tuberculosis drug resistance should be repeated annually. Measures to decrease the multidrug-resistance rate are greatly needed.

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