Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan

Jen J. Lee, Chun N. Lee, Jen Suo, I. Hsin Chiang, Chin B. Lin, Teng Y. Lin, Yeong C. Tsai

研究成果: 雜誌貢獻文章

10 引文 斯高帕斯(Scopus)

摘要

Objective: To evaluate patterns of drug resistance of Mycobacterium tuberculosis in eastern Taiwan. Materials and Methods: Two hundred and fifty-two isolates collected from January 2001 through December 2002 were tested for drug susceptibility using the agar proportion method at Tzu Chi General Hospital. Results: The overall rate of resistance to at least one drug was 28.6%. The overall resistance rates to individual drugs were 21.8% to isoniazid, 8.3% to streptomycin, 12.7% to rifampin, and 12.7% to ethambutol. Among the 190 isolates from patients without prior treatment, 16.8% of the strains were resistant to at least one drug. Resistance to isoniazid (11.1%), ethambutol (5.8%), or streptomycin (5.3%) was more common than resistance to rifampin (2.1%). The prevalence of primary multidrug resistance was 2.1%. Among the 62 isolates from patients with histories of anti-TB treatment, the prevalence of resistance to any of the four drugs was 64.5%. The acquired resistance rates to individual drugs were 54.8% to isoniazid, 17.7% to streptomycin, 45.2% to rifampin, and 33.9% to ethambutol. Conclusions: The prevalence of drug resistance is very high in eastern Taiwan, and the surveys for anti-tuberculosis drug resistance should be repeated annually. Measures to decrease the multidrug-resistance rate are greatly needed.
原文英語
頁(從 - 到)229-234
頁數6
期刊Tzu Chi Medical Journal
15
發行號4
出版狀態已發佈 - 八月 2003

ASJC Scopus subject areas

  • Medicine(all)

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  • 引用此

    Lee, J. J., Lee, C. N., Suo, J., Chiang, I. H., Lin, C. B., Lin, T. Y., & Tsai, Y. C. (2003). Drug resistance of Mycobacterium tuberculosis in Eastern Taiwan. Tzu Chi Medical Journal, 15(4), 229-234.