Drug release from hydroxypropyl cellulose and polyethylene oxide capsules: In vitro and in vivo assessment

Chien Yuan Lee, Gan Lin Chen, Ming Thau Sheu, Cheng Hsiung Liu

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

In this study, hard capsule shells produced using a heat-melting method, which involved heating polyethylene oxide (PEO, with a molecular weight (MW) of 200,000) or hydroxypropyl cellulose (HPC, with MWs of 80,000,100,000, and 370,000) powder in a mold, followed by inserting a suitably sized pestle in the mold in order to coat the melted shell materials (HPC or PEO) onto the pestle with a certain force. The water uptake and dissolution tests of these capsule shells were evaluated in acidic buffer, basic buffer, and water. Theophylline was selected as the model drug. The drug release rate decreased with increasing viscosity grades of HPC used as the shell material. In vivo studies were conducted in rabbits with the novel capsules, and comparisons were made with gelatin capsules. It was found that the pharmacokinetic parameters, including AUC0-∞ and T1/2, showed no significant differences among the various capsules. Correlations between the in vitro TD50 values and several in vivo parameters were established.

原文英語
頁(從 - 到)57-65
頁數9
期刊Chinese Pharmaceutical Journal
58
發行號1
出版狀態已發佈 - 2月 2006

ASJC Scopus subject areas

  • 藥學科學
  • 生物工程

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