Downregulated myocardial connexin 43 and suppressed contractility in rabbits subjected to a cholesterol-enriched diet

Lung Chun Lin, Chau Chung Wu, Hung I. Yeh, Long Sheng Lu, Yen Bin Liu, Shien Fong Lin, Yuan Teh Lee

研究成果: 雜誌貢獻文章

25 引文 斯高帕斯(Scopus)

摘要

The effects of hypercholesterolemia on the myocardium per se include electrophysiological and mechanical alterations. Since gap junctions are essential in electromechanical coupling throughout the heart, we examined the correlation between the temporal expression of cardiac connexin 43 (Cx43), contractile function, and conduction velocity in cholesterol-fed rabbits. After a 12-week feeding period, serum cholesterol levels gradually increased (P

原文英語
頁(從 - 到)1224-1237
頁數14
期刊Laboratory Investigation
85
發行號10
DOIs
出版狀態已發佈 - 十月 2005
對外發佈Yes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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