Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic

Hung Yi Chiou, Wei I. Huang, Che Long Su, Shu Feng Chang, Yi Hsiang Hsu, Chien Jen Chen

研究成果: 雜誌貢獻文章

237 引文 (Scopus)

摘要

Background and Purpose: Circulatory diseases such as ischemic heart disease and peripheral vascular disease induced by long-term arsenic exposure have been well documented in previous studies, but the close-response relationship between cerebrovascular disease and ingested inorganic arsenic remains to be elucidated. The prevalence of cerebrovascular disease among residents of the Lanyang Basin on the northeast coast of Taiwan was surveyed to examine its association with exposure to arsenic in well water. Methods: A total of 8102 men and women from 3901 households were recruited in this study. The status of cerebrovascular disease of study subjects was identified through home-visit personal interviews and ascertained by review of hospital medical records according to the World Health Organization criteria. Information on consumption of well water, sociodemographic characteristics, cigarette smoking, and alcohol consumption habits, as well as personal and family history of diseases, was also obtained. Arsenic concentration in the well water of each household was determined by hydride generation and atomic absorption spectrometry. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95% confidence intervals for various risk factors of cerebrovascular disease. Results: A significant dose-response relationship was observed between arsenic concentration in well water and prevalence of cerebrovascular disease after adjustment for age, sex, hypertension, diabetes mellitus, cigarette smoking, and alcohol consumption. The biological gradient was even more prominent for cerebral infarction, showing multivariate-adjusted odds ratios of 1.0, 3.4, 4.5, and 6.9, respectively, for those who consumed well water with an arsenic content of 0, 0.1 to 50.0 50.1 to 299.9, and >300 μg/L. Conclusions: Long-term exposure to inorganic arsenic from well water was associated with an increased prevalence of cerebrovascular disease, especially cerebral infarction.

原文英語
頁(從 - 到)1717-1723
頁數7
期刊Stroke
28
發行號9
出版狀態已發佈 - 九月 1997

指紋

Cerebrovascular Disorders
Arsenic
Water
Cerebral Infarction
Alcohol Drinking
Smoking
Odds Ratio
House Calls
Peripheral Vascular Diseases
Hospital Records
Taiwan
Drinking
Habits
Medical Records
Myocardial Ischemia
Spectrum Analysis
Diabetes Mellitus
Logistic Models
Regression Analysis
Confidence Intervals

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

引用此文

Chiou, H. Y., Huang, W. I., Su, C. L., Chang, S. F., Hsu, Y. H., & Chen, C. J. (1997). Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. Stroke, 28(9), 1717-1723.

Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. / Chiou, Hung Yi; Huang, Wei I.; Su, Che Long; Chang, Shu Feng; Hsu, Yi Hsiang; Chen, Chien Jen.

於: Stroke, 卷 28, 編號 9, 09.1997, p. 1717-1723.

研究成果: 雜誌貢獻文章

Chiou, HY, Huang, WI, Su, CL, Chang, SF, Hsu, YH & Chen, CJ 1997, 'Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic', Stroke, 卷 28, 編號 9, 頁 1717-1723.
Chiou, Hung Yi ; Huang, Wei I. ; Su, Che Long ; Chang, Shu Feng ; Hsu, Yi Hsiang ; Chen, Chien Jen. / Dose-response relationship between prevalence of cerebrovascular disease and ingested inorganic arsenic. 於: Stroke. 1997 ; 卷 28, 編號 9. 頁 1717-1723.
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abstract = "Background and Purpose: Circulatory diseases such as ischemic heart disease and peripheral vascular disease induced by long-term arsenic exposure have been well documented in previous studies, but the close-response relationship between cerebrovascular disease and ingested inorganic arsenic remains to be elucidated. The prevalence of cerebrovascular disease among residents of the Lanyang Basin on the northeast coast of Taiwan was surveyed to examine its association with exposure to arsenic in well water. Methods: A total of 8102 men and women from 3901 households were recruited in this study. The status of cerebrovascular disease of study subjects was identified through home-visit personal interviews and ascertained by review of hospital medical records according to the World Health Organization criteria. Information on consumption of well water, sociodemographic characteristics, cigarette smoking, and alcohol consumption habits, as well as personal and family history of diseases, was also obtained. Arsenic concentration in the well water of each household was determined by hydride generation and atomic absorption spectrometry. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95{\%} confidence intervals for various risk factors of cerebrovascular disease. Results: A significant dose-response relationship was observed between arsenic concentration in well water and prevalence of cerebrovascular disease after adjustment for age, sex, hypertension, diabetes mellitus, cigarette smoking, and alcohol consumption. The biological gradient was even more prominent for cerebral infarction, showing multivariate-adjusted odds ratios of 1.0, 3.4, 4.5, and 6.9, respectively, for those who consumed well water with an arsenic content of 0, 0.1 to 50.0 50.1 to 299.9, and >300 μg/L. Conclusions: Long-term exposure to inorganic arsenic from well water was associated with an increased prevalence of cerebrovascular disease, especially cerebral infarction.",
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AU - Chiou, Hung Yi

AU - Huang, Wei I.

AU - Su, Che Long

AU - Chang, Shu Feng

AU - Hsu, Yi Hsiang

AU - Chen, Chien Jen

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N2 - Background and Purpose: Circulatory diseases such as ischemic heart disease and peripheral vascular disease induced by long-term arsenic exposure have been well documented in previous studies, but the close-response relationship between cerebrovascular disease and ingested inorganic arsenic remains to be elucidated. The prevalence of cerebrovascular disease among residents of the Lanyang Basin on the northeast coast of Taiwan was surveyed to examine its association with exposure to arsenic in well water. Methods: A total of 8102 men and women from 3901 households were recruited in this study. The status of cerebrovascular disease of study subjects was identified through home-visit personal interviews and ascertained by review of hospital medical records according to the World Health Organization criteria. Information on consumption of well water, sociodemographic characteristics, cigarette smoking, and alcohol consumption habits, as well as personal and family history of diseases, was also obtained. Arsenic concentration in the well water of each household was determined by hydride generation and atomic absorption spectrometry. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95% confidence intervals for various risk factors of cerebrovascular disease. Results: A significant dose-response relationship was observed between arsenic concentration in well water and prevalence of cerebrovascular disease after adjustment for age, sex, hypertension, diabetes mellitus, cigarette smoking, and alcohol consumption. The biological gradient was even more prominent for cerebral infarction, showing multivariate-adjusted odds ratios of 1.0, 3.4, 4.5, and 6.9, respectively, for those who consumed well water with an arsenic content of 0, 0.1 to 50.0 50.1 to 299.9, and >300 μg/L. Conclusions: Long-term exposure to inorganic arsenic from well water was associated with an increased prevalence of cerebrovascular disease, especially cerebral infarction.

AB - Background and Purpose: Circulatory diseases such as ischemic heart disease and peripheral vascular disease induced by long-term arsenic exposure have been well documented in previous studies, but the close-response relationship between cerebrovascular disease and ingested inorganic arsenic remains to be elucidated. The prevalence of cerebrovascular disease among residents of the Lanyang Basin on the northeast coast of Taiwan was surveyed to examine its association with exposure to arsenic in well water. Methods: A total of 8102 men and women from 3901 households were recruited in this study. The status of cerebrovascular disease of study subjects was identified through home-visit personal interviews and ascertained by review of hospital medical records according to the World Health Organization criteria. Information on consumption of well water, sociodemographic characteristics, cigarette smoking, and alcohol consumption habits, as well as personal and family history of diseases, was also obtained. Arsenic concentration in the well water of each household was determined by hydride generation and atomic absorption spectrometry. Logistic regression analysis was used to estimate multivariate-adjusted odds ratios and 95% confidence intervals for various risk factors of cerebrovascular disease. Results: A significant dose-response relationship was observed between arsenic concentration in well water and prevalence of cerebrovascular disease after adjustment for age, sex, hypertension, diabetes mellitus, cigarette smoking, and alcohol consumption. The biological gradient was even more prominent for cerebral infarction, showing multivariate-adjusted odds ratios of 1.0, 3.4, 4.5, and 6.9, respectively, for those who consumed well water with an arsenic content of 0, 0.1 to 50.0 50.1 to 299.9, and >300 μg/L. Conclusions: Long-term exposure to inorganic arsenic from well water was associated with an increased prevalence of cerebrovascular disease, especially cerebral infarction.

KW - Arsenic

KW - Cerebrovascular disorders

KW - Hypertension

KW - Risk factors

KW - Water pollution

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