Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan

Lai Chu See, Hung-Yi Chiou, Jiahn Shing Lee, Yu-Mei Hsueh, Shu Mei Lin, Ming Chang Tu, Meng Ling Yang, Chien Jen Chen

研究成果: 雜誌貢獻 › 文章

15 引文 (Scopus)

摘要

This association study was carried out to examine the effect of long-term exposure to ingested arsenic on various types of cataract. A total of 349 residents living in arseniasis-hyperendemic villages of southwestern Taiwan were recruited. Cumulative arsenic exposure was derived from the history of consuming artesian well water and the arsenic level in well water. The Lens Opacities System III was used to classify different types of cataract. The cataract surgery prevalence was 10% for the age group of 50 or more years. Cortical opacity was most common (35%), while nuclear and posterior subcapsular opacities were observed in 24% and 22% of subjects, respectively. Diabetes mellitus was a significant risk factor for all types of cataract. Occupational sunlight exposure was associated with cortical and posterior subcapsular opacities in a dose-response relationship. The cumulative exposure to arsenic from artesian well water and the duration of consuming artesian well water were associated with an increased risk of all types of lens opacity. But statistically significant dose-response relations with the cumulative arsenic exposure and the duration of consuming artesian well water were observed only for posterior subcapsular opacity (P = 0.014 and P = 0.023, respectively) after adjustment for age, sex, diabetes status, and occupational sunlight exposure. It was concluded that there was an increasing prevalence of posterior subcapsular opacity with the increase in exposure to ingested arsenic.
原文英語
頁（從 - 到）1843-1851
頁數9
期刊Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering
卷42
發行號12
DOIs
出版狀態已發佈 - 十月 2007

指紋

dose-response relationship
Opacity
Arsenic
artesian well
arsenic
well water
Water
diabetes
occupational exposure
Medical problems
Lenses
risk factor
Surgery
village
exposure
history

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Science(all)
  • Environmental Chemistry

引用此文

Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan. / See, Lai Chu; Chiou, Hung-Yi; Lee, Jiahn Shing; Hsueh, Yu-Mei; Lin, Shu Mei; Tu, Ming Chang; Yang, Meng Ling; Chen, Chien Jen.

於: Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, 卷 42, 編號 12, 10.2007, p. 1843-1851.

研究成果: 雜誌貢獻 › 文章

See, LC, Chiou, H-Y, Lee, JS, Hsueh, Y-M, Lin, SM, Tu, MC, Yang, ML & Chen, CJ 2007, 'Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan', Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering, 卷 42, 編號 12, 頁 1843-1851. https://doi.org/10.1080/10934520701566884
See LC, Chiou H-Y, Lee JS, Hsueh Y-M, Lin SM, Tu MC 等. Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan. Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering. 2007 10月;42(12):1843-1851. https://doi.org/10.1080/10934520701566884
See, Lai Chu ; Chiou, Hung-Yi ; Lee, Jiahn Shing ; Hsueh, Yu-Mei ; Lin, Shu Mei ; Tu, Ming Chang ; Yang, Meng Ling ; Chen, Chien Jen. / Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan. 於: Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering. 2007 ; 卷 42, 編號 12. 頁 1843-1851.
@article{51d64d0a6bca409190023802a5ec90dd,
title = "Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan",
abstract = "This association study was carried out to examine the effect of long-term exposure to ingested arsenic on various types of cataract. A total of 349 residents living in arseniasis-hyperendemic villages of southwestern Taiwan were recruited. Cumulative arsenic exposure was derived from the history of consuming artesian well water and the arsenic level in well water. The Lens Opacities System III was used to classify different types of cataract. The cataract surgery prevalence was 10{\%} for the age group of 50 or more years. Cortical opacity was most common (35{\%}), while nuclear and posterior subcapsular opacities were observed in 24{\%} and 22{\%} of subjects, respectively. Diabetes mellitus was a significant risk factor for all types of cataract. Occupational sunlight exposure was associated with cortical and posterior subcapsular opacities in a dose-response relationship. The cumulative exposure to arsenic from artesian well water and the duration of consuming artesian well water were associated with an increased risk of all types of lens opacity. But statistically significant dose-response relations with the cumulative arsenic exposure and the duration of consuming artesian well water were observed only for posterior subcapsular opacity (P = 0.014 and P = 0.023, respectively) after adjustment for age, sex, diabetes status, and occupational sunlight exposure. It was concluded that there was an increasing prevalence of posterior subcapsular opacity with the increase in exposure to ingested arsenic.",
keywords = "Cataract, Ingested arsenic, Posterior subcapsular opacities, Prevalence",
author = "See, {Lai Chu} and Hung-Yi Chiou and Lee, {Jiahn Shing} and Yu-Mei Hsueh and Lin, {Shu Mei} and Tu, {Ming Chang} and Yang, {Meng Ling} and Chen, {Chien Jen}",
year = "2007",
month = "10",
doi = "10.1080/10934520701566884",
language = "English",
volume = "42",
pages = "1843--1851",
journal = "Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering",
issn = "1093-4529",
publisher = "Taylor and Francis Ltd.",
number = "12",

}

TY - JOUR

T1 - Dose-response relationship between ingested arsenic and cataracts among residents in Southwestern Taiwan

AU - See, Lai Chu

AU - Chiou, Hung-Yi

AU - Lee, Jiahn Shing

AU - Hsueh, Yu-Mei

AU - Lin, Shu Mei

AU - Tu, Ming Chang

AU - Yang, Meng Ling

AU - Chen, Chien Jen

PY - 2007/10

Y1 - 2007/10

N2 - This association study was carried out to examine the effect of long-term exposure to ingested arsenic on various types of cataract. A total of 349 residents living in arseniasis-hyperendemic villages of southwestern Taiwan were recruited. Cumulative arsenic exposure was derived from the history of consuming artesian well water and the arsenic level in well water. The Lens Opacities System III was used to classify different types of cataract. The cataract surgery prevalence was 10% for the age group of 50 or more years. Cortical opacity was most common (35%), while nuclear and posterior subcapsular opacities were observed in 24% and 22% of subjects, respectively. Diabetes mellitus was a significant risk factor for all types of cataract. Occupational sunlight exposure was associated with cortical and posterior subcapsular opacities in a dose-response relationship. The cumulative exposure to arsenic from artesian well water and the duration of consuming artesian well water were associated with an increased risk of all types of lens opacity. But statistically significant dose-response relations with the cumulative arsenic exposure and the duration of consuming artesian well water were observed only for posterior subcapsular opacity (P = 0.014 and P = 0.023, respectively) after adjustment for age, sex, diabetes status, and occupational sunlight exposure. It was concluded that there was an increasing prevalence of posterior subcapsular opacity with the increase in exposure to ingested arsenic.

AB - This association study was carried out to examine the effect of long-term exposure to ingested arsenic on various types of cataract. A total of 349 residents living in arseniasis-hyperendemic villages of southwestern Taiwan were recruited. Cumulative arsenic exposure was derived from the history of consuming artesian well water and the arsenic level in well water. The Lens Opacities System III was used to classify different types of cataract. The cataract surgery prevalence was 10% for the age group of 50 or more years. Cortical opacity was most common (35%), while nuclear and posterior subcapsular opacities were observed in 24% and 22% of subjects, respectively. Diabetes mellitus was a significant risk factor for all types of cataract. Occupational sunlight exposure was associated with cortical and posterior subcapsular opacities in a dose-response relationship. The cumulative exposure to arsenic from artesian well water and the duration of consuming artesian well water were associated with an increased risk of all types of lens opacity. But statistically significant dose-response relations with the cumulative arsenic exposure and the duration of consuming artesian well water were observed only for posterior subcapsular opacity (P = 0.014 and P = 0.023, respectively) after adjustment for age, sex, diabetes status, and occupational sunlight exposure. It was concluded that there was an increasing prevalence of posterior subcapsular opacity with the increase in exposure to ingested arsenic.

KW - Cataract

KW - Ingested arsenic

KW - Posterior subcapsular opacities

KW - Prevalence

UR - http://www.scopus.com/inward/record.url?scp=35348948117&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35348948117&partnerID=8YFLogxK

U2 - 10.1080/10934520701566884

DO - 10.1080/10934520701566884

M3 - Article

C2 - 17952785

AN - SCOPUS:35348948117

VL - 42

SP - 1843

EP - 1851

JO - Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering

JF - Journal of Environmental Science and Health - Part A Toxic/Hazardous Substances and Environmental Engineering

SN - 1093-4529

IS - 12

ER -

存取文件