Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study

L. I. Hsu, K. H. Hsu, H. Y. Chiou, C. J. Chen

研究成果: 書貢獻/報告類型會議貢獻

1 引文 斯高帕斯(Scopus)

摘要

The association of arsenic exposure with Chronic Kidney Disease (CKD) has never been reported in low-to-moderate exposed area in Taiwan. The aim of this study is to examine the dose-response relationship between ingested arsenic and CKD in northeastern Taiwan where well arsenic ranged from undetectable to 3590 μg/L. A total of 6,153 participants were followed 1998–2011. The disease status was ascertained through linkage with National Health Insurance database. Cox regression analysis was used to determine the hazard ratio of the disease associated with arsenic exposure. The dose-response relationship between two arsenic exposure indices and CKD was observed. Hazard ratio was 1.00, 0.92 (95% confidence interval (CI), 0.66–1.28), 1.20 (95%CI, 0.90–1.60), 1.46 (95%CI,1.09–1.95), 1.08 (95%CI,0.80– 1.49) and 1.58 (95%CI,1.14–2.18) in relation to well water arsenic concentration of <10.0, 10.0–24.9, 25.0–49.9, 50.0–99.9, 100.0–499.9 and ≥ 500.0 μg/L (Ptrend:0.0099). Significantly increased CKD risk was observed among people consuming contaminated water with arsenic concentration >50 μg/L.
原文英語
主出版物標題Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
發行者CRC Press/Balkema
頁面361-362
頁數2
ISBN(列印)9781138029415
出版狀態已發佈 - 2016
事件6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, 瑞典
持續時間: 六月 19 2016六月 23 2016

會議

會議6th International Congress on Arsenic in the Environment, AS 2016
國家瑞典
城市Stockholm
期間6/19/166/23/16

ASJC Scopus subject areas

  • Pollution
  • Environmental Chemistry

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    Hsu, L. I., Hsu, K. H., Chiou, H. Y., & Chen, C. J. (2016). Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study. 於 Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016 (頁 361-362). CRC Press/Balkema.