Dopamine release impairment in striatum after different levels of cerebral cortical fluid percussion injury

Yuan Hao Chen, Eagle Yi Kung Huang, Tung Tai Kuo, Hsin I. Ma, Barry J. Hoffer, Pi Fen Tsui, Jing Jr Tsai, Yu Ching Chou, Yung-Hsiao Chiang

研究成果: 雜誌貢獻文章

15 引文 (Scopus)

摘要

To investigate the role of dopamine release in cognitive impairment and motor learning deficits after brain injury, different levels of traumatic brain injury (TBI) were made in rats by using fluid percussion at two different atmospheres (2 Psi and 6 Psi). Tonic and phasic bursting dopamine release and behavior tests followed at several time points. We used in vitro fast-scan cyclic voltammetry to survey dopamine release in the striatum and analyzed the rats’ behavior using novel object recognition (NOR) and rotarod tests. Both tonic and bursting dopamine release were greatly depressed in the severely (6 Psi) injured group, which persisted up to 8 weeks later. However, in the 2 Psi-injured group, the suppression of bursting dopamine release occurred at 1~2 weeks after injury, but there were no significant differences after 4 weeks. Tonic dopamine release was also diminished significantly at 1~2 weeks after the injury; partial recovery could then be seen 4 weeks after injury. A significant deficiency in the fixed speed rotarod test and NOR test were noted in both 2 Psi and 6 Psi groups initially; however, the changes recovered in the 2 Psi group 2 weeks after injury while persisting in the 6 Psi group. In conclusion, striatal evoked dopamine release was affected by fluid percussion injury, with behavioral deficits showing differences as a function of injury severity. The severe fluid percussion injury (6 Psi) group showed more dopamine release defects, as well as cognitive and motor deficiencies. Recovery of dopamine release and improvement in behavioral impairment were better in the mild TBI group.
原文英語
頁(從 - 到)2113-2128
頁數16
期刊Cell Transplantation
24
發行號10
DOIs
出版狀態已發佈 - 十月 13 2015

指紋

Percussion
Dopamine
Fluids
Wounds and Injuries
Rotarod Performance Test
Brain
Object recognition
Rats
Brain Concussion
Corpus Striatum
Recovery
Atmosphere
Brain Injuries
Cyclic voltammetry
Learning
Defects

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation
  • Biomedical Engineering

引用此文

Dopamine release impairment in striatum after different levels of cerebral cortical fluid percussion injury. / Chen, Yuan Hao; Huang, Eagle Yi Kung; Kuo, Tung Tai; Ma, Hsin I.; Hoffer, Barry J.; Tsui, Pi Fen; Tsai, Jing Jr; Chou, Yu Ching; Chiang, Yung-Hsiao.

於: Cell Transplantation, 卷 24, 編號 10, 13.10.2015, p. 2113-2128.

研究成果: 雜誌貢獻文章

Chen, YH, Huang, EYK, Kuo, TT, Ma, HI, Hoffer, BJ, Tsui, PF, Tsai, JJ, Chou, YC & Chiang, Y-H 2015, 'Dopamine release impairment in striatum after different levels of cerebral cortical fluid percussion injury', Cell Transplantation, 卷 24, 編號 10, 頁 2113-2128. https://doi.org/10.3727/096368914X683584
Chen, Yuan Hao ; Huang, Eagle Yi Kung ; Kuo, Tung Tai ; Ma, Hsin I. ; Hoffer, Barry J. ; Tsui, Pi Fen ; Tsai, Jing Jr ; Chou, Yu Ching ; Chiang, Yung-Hsiao. / Dopamine release impairment in striatum after different levels of cerebral cortical fluid percussion injury. 於: Cell Transplantation. 2015 ; 卷 24, 編號 10. 頁 2113-2128.
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abstract = "To investigate the role of dopamine release in cognitive impairment and motor learning deficits after brain injury, different levels of traumatic brain injury (TBI) were made in rats by using fluid percussion at two different atmospheres (2 Psi and 6 Psi). Tonic and phasic bursting dopamine release and behavior tests followed at several time points. We used in vitro fast-scan cyclic voltammetry to survey dopamine release in the striatum and analyzed the rats’ behavior using novel object recognition (NOR) and rotarod tests. Both tonic and bursting dopamine release were greatly depressed in the severely (6 Psi) injured group, which persisted up to 8 weeks later. However, in the 2 Psi-injured group, the suppression of bursting dopamine release occurred at 1~2 weeks after injury, but there were no significant differences after 4 weeks. Tonic dopamine release was also diminished significantly at 1~2 weeks after the injury; partial recovery could then be seen 4 weeks after injury. A significant deficiency in the fixed speed rotarod test and NOR test were noted in both 2 Psi and 6 Psi groups initially; however, the changes recovered in the 2 Psi group 2 weeks after injury while persisting in the 6 Psi group. In conclusion, striatal evoked dopamine release was affected by fluid percussion injury, with behavioral deficits showing differences as a function of injury severity. The severe fluid percussion injury (6 Psi) group showed more dopamine release defects, as well as cognitive and motor deficiencies. Recovery of dopamine release and improvement in behavioral impairment were better in the mild TBI group.",
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AU - Hoffer, Barry J.

AU - Tsui, Pi Fen

AU - Tsai, Jing Jr

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AB - To investigate the role of dopamine release in cognitive impairment and motor learning deficits after brain injury, different levels of traumatic brain injury (TBI) were made in rats by using fluid percussion at two different atmospheres (2 Psi and 6 Psi). Tonic and phasic bursting dopamine release and behavior tests followed at several time points. We used in vitro fast-scan cyclic voltammetry to survey dopamine release in the striatum and analyzed the rats’ behavior using novel object recognition (NOR) and rotarod tests. Both tonic and bursting dopamine release were greatly depressed in the severely (6 Psi) injured group, which persisted up to 8 weeks later. However, in the 2 Psi-injured group, the suppression of bursting dopamine release occurred at 1~2 weeks after injury, but there were no significant differences after 4 weeks. Tonic dopamine release was also diminished significantly at 1~2 weeks after the injury; partial recovery could then be seen 4 weeks after injury. A significant deficiency in the fixed speed rotarod test and NOR test were noted in both 2 Psi and 6 Psi groups initially; however, the changes recovered in the 2 Psi group 2 weeks after injury while persisting in the 6 Psi group. In conclusion, striatal evoked dopamine release was affected by fluid percussion injury, with behavioral deficits showing differences as a function of injury severity. The severe fluid percussion injury (6 Psi) group showed more dopamine release defects, as well as cognitive and motor deficiencies. Recovery of dopamine release and improvement in behavioral impairment were better in the mild TBI group.

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