Does indomethacin affect the control of breathing in premature infants?

T. F. Yeh, A. Wilks

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

The effect of indomethacin on the control of breathing was simultaneously evaluated in 10 premature infants who had significant patent ductus arteriosus and received indomethacin therapy. In an attempt to maintain high plasma level in these infants of advanced postnatal age (≥6 weeks), indomethacin was administered intravenously at a dosage of 0.3 mg/kg, at 8-hour intervals, for a total of three doses. Following indomethacin therapy, there was a significant increase in tidal volume, minute ventilation, tidal volume/inspiratory time and in airway pressure (P0.1, P(max)) generated during airway occlusion. Seven infants required lower ventilatory rates after study. In spite of desirable plasma indomethacin level, there was no significant improvement in echo left atrium/aortic root dimension ratio, cardiovascular dysfunction score and blood pH, PO2 and PCO2. None of the infants showed clinical evidence of ductus closure. The results of the study suggested that indomethacin may stimulate respiration and that endogenous prostaglandin may play a role in the regulation of breathing.

原文英語
頁(從 - 到)211-216
頁數6
期刊Developmental Pharmacology and Therapeutics
12
發行號4
出版狀態已發佈 - 一月 1 1989
對外發佈Yes

指紋

Premature Infants
Indomethacin
Respiration
Tidal Volume
Patent Ductus Arteriosus
Heart Atria
Prostaglandins
Ventilation
Pressure
Therapeutics

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

引用此文

Does indomethacin affect the control of breathing in premature infants? / Yeh, T. F.; Wilks, A.

於: Developmental Pharmacology and Therapeutics, 卷 12, 編號 4, 01.01.1989, p. 211-216.

研究成果: 雜誌貢獻文章

@article{600f0f932217449d9c92bcad5762f47a,
title = "Does indomethacin affect the control of breathing in premature infants?",
abstract = "The effect of indomethacin on the control of breathing was simultaneously evaluated in 10 premature infants who had significant patent ductus arteriosus and received indomethacin therapy. In an attempt to maintain high plasma level in these infants of advanced postnatal age (≥6 weeks), indomethacin was administered intravenously at a dosage of 0.3 mg/kg, at 8-hour intervals, for a total of three doses. Following indomethacin therapy, there was a significant increase in tidal volume, minute ventilation, tidal volume/inspiratory time and in airway pressure (P0.1, P(max)) generated during airway occlusion. Seven infants required lower ventilatory rates after study. In spite of desirable plasma indomethacin level, there was no significant improvement in echo left atrium/aortic root dimension ratio, cardiovascular dysfunction score and blood pH, PO2 and PCO2. None of the infants showed clinical evidence of ductus closure. The results of the study suggested that indomethacin may stimulate respiration and that endogenous prostaglandin may play a role in the regulation of breathing.",
author = "Yeh, {T. F.} and A. Wilks",
year = "1989",
month = "1",
day = "1",
language = "English",
volume = "12",
pages = "211--216",
journal = "Developmental Pharmacology and Therapeutics",
issn = "0379-8305",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Does indomethacin affect the control of breathing in premature infants?

AU - Yeh, T. F.

AU - Wilks, A.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - The effect of indomethacin on the control of breathing was simultaneously evaluated in 10 premature infants who had significant patent ductus arteriosus and received indomethacin therapy. In an attempt to maintain high plasma level in these infants of advanced postnatal age (≥6 weeks), indomethacin was administered intravenously at a dosage of 0.3 mg/kg, at 8-hour intervals, for a total of three doses. Following indomethacin therapy, there was a significant increase in tidal volume, minute ventilation, tidal volume/inspiratory time and in airway pressure (P0.1, P(max)) generated during airway occlusion. Seven infants required lower ventilatory rates after study. In spite of desirable plasma indomethacin level, there was no significant improvement in echo left atrium/aortic root dimension ratio, cardiovascular dysfunction score and blood pH, PO2 and PCO2. None of the infants showed clinical evidence of ductus closure. The results of the study suggested that indomethacin may stimulate respiration and that endogenous prostaglandin may play a role in the regulation of breathing.

AB - The effect of indomethacin on the control of breathing was simultaneously evaluated in 10 premature infants who had significant patent ductus arteriosus and received indomethacin therapy. In an attempt to maintain high plasma level in these infants of advanced postnatal age (≥6 weeks), indomethacin was administered intravenously at a dosage of 0.3 mg/kg, at 8-hour intervals, for a total of three doses. Following indomethacin therapy, there was a significant increase in tidal volume, minute ventilation, tidal volume/inspiratory time and in airway pressure (P0.1, P(max)) generated during airway occlusion. Seven infants required lower ventilatory rates after study. In spite of desirable plasma indomethacin level, there was no significant improvement in echo left atrium/aortic root dimension ratio, cardiovascular dysfunction score and blood pH, PO2 and PCO2. None of the infants showed clinical evidence of ductus closure. The results of the study suggested that indomethacin may stimulate respiration and that endogenous prostaglandin may play a role in the regulation of breathing.

UR - http://www.scopus.com/inward/record.url?scp=0024405908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024405908&partnerID=8YFLogxK

M3 - Article

C2 - 2766924

AN - SCOPUS:0024405908

VL - 12

SP - 211

EP - 216

JO - Developmental Pharmacology and Therapeutics

JF - Developmental Pharmacology and Therapeutics

SN - 0379-8305

IS - 4

ER -