Do stress and long-term potentiation share the same molecular mechanisms?

Chiung Chun Huang, Chih Hao Yang, Kuei Sen Hsu

研究成果: 雜誌貢獻回顧型文獻同行評審

43 引文 斯高帕斯(Scopus)


Stress is a biological, significant factor shown to influence hippocampal synaptic plasticity and cognitive functions. Although numerous studies have reported that stress produces a suppression in long-term potentiation (LTP; a putative synaptic mechanism underlying learning and memory), little is known about the mechanism by which this occurs. Because the effects of stress on LTP and its converse process, long-term depression (LTD), parallel the changes in synaptic plasticity that occur following the establishment of LTP with tetanic stimulation (i.e., occluding LTP and enhancing LTD induction), it has been proposed that stress affects subsequent hippocampal plasticity by sharing the same molecular machinery required to support LTP This article summarizes recent findings from ours and other laboratories to assess this view and discusses relevant hypotheses in the study of stress-related modifications of synaptic plasticity.
頁(從 - 到)223-235
期刊Molecular Neurobiology
出版狀態已發佈 - 十二月 2005

ASJC Scopus subject areas

  • 神經內科
  • 細胞與分子神經科學


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