DNA microarray analysis of the effect on inflammation in patients treated with acupuncture for allergic rhinitis

Horng Sheng Shiue, Yun Shien Lee, Chi N. Tsai, Yu M. Hsueh, Joen Rong Sheu, Hen Hong Chang

研究成果: 雜誌貢獻文章

31 引文 (Scopus)

摘要

Background: Allergic rhinitis affects approximately 30% of adults and up to 40% of children in industrialized societies. Medicines available for relief of allergic rhinitis symptoms include antihistamines, decongestants, leukotriene inhibitors, topical hormones, and corticosteroids. However, the negative side-effects of antiallergic medicines cause many patients with allergic rhinitis to choose traditional Chinese medical treatments, such as taking Chinese herbs or treatment with acupuncture. Objectives: This study assessed the effect of acupuncture for treatment of allergic rhinitis. Methods: Eighteen (18) patients with allergic rhinitis were treated with acupuncture 8 times over a 4-week period, and peripheral blood of these patients was collected at each visit for analysis of gene expression via cDNA microarray. To estimate the therapeutic effect of acupuncture objectively, patients completed the rhinoconjunctivitis quality of life questionnaire (RQLQ) before and after acupuncture therapy. Results: Based upon patients' response to the RQLQ, acupuncture therapy significantly reduced allergic rhinitis symptoms, including nasal symptoms, non-hay fever symptoms, and sleep and practical problems (associated with daily activities). In addition, expression of interleukin-1 receptor-α (IL1R1) in peripheral blood was significantly decreased at 2 hours, 24 hours, and 4 weeks after acupuncture treatment in these patients. Conclusions: To our knowledge, this is the first report of cDNA microarray analysis of differential gene expression in the peripheral blood of patients with allergic rhinitis before and after acupuncture treatment. Our data suggest that the balance between T-helper 1 and T-helper 2 cell-derived proinflammatory versus anti-inflammatory cytokines might be improved by acupuncture treatment.

原文英語
頁(從 - 到)689-698
頁數10
期刊Journal of Alternative and Complementary Medicine
14
發行號6
DOIs
出版狀態已發佈 - 七月 1 2008

指紋

Acupuncture Therapy
Acupuncture
Microarray Analysis
Oligonucleotide Array Sequence Analysis
Inflammation
Quality of Life
Nasal Decongestants
Gene Expression
Anti-Allergic Agents
Th2 Cells
Interleukin-1 Receptors
Leukotrienes
Histamine Antagonists
Therapeutic Uses
Allergic Rhinitis
Nose
Adrenal Cortex Hormones
Sleep
Anti-Inflammatory Agents
Fever

ASJC Scopus subject areas

  • Medicine(all)
  • Complementary and alternative medicine
  • Nursing(all)

引用此文

DNA microarray analysis of the effect on inflammation in patients treated with acupuncture for allergic rhinitis. / Shiue, Horng Sheng; Lee, Yun Shien; Tsai, Chi N.; Hsueh, Yu M.; Sheu, Joen Rong; Chang, Hen Hong.

於: Journal of Alternative and Complementary Medicine, 卷 14, 編號 6, 01.07.2008, p. 689-698.

研究成果: 雜誌貢獻文章

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abstract = "Background: Allergic rhinitis affects approximately 30{\%} of adults and up to 40{\%} of children in industrialized societies. Medicines available for relief of allergic rhinitis symptoms include antihistamines, decongestants, leukotriene inhibitors, topical hormones, and corticosteroids. However, the negative side-effects of antiallergic medicines cause many patients with allergic rhinitis to choose traditional Chinese medical treatments, such as taking Chinese herbs or treatment with acupuncture. Objectives: This study assessed the effect of acupuncture for treatment of allergic rhinitis. Methods: Eighteen (18) patients with allergic rhinitis were treated with acupuncture 8 times over a 4-week period, and peripheral blood of these patients was collected at each visit for analysis of gene expression via cDNA microarray. To estimate the therapeutic effect of acupuncture objectively, patients completed the rhinoconjunctivitis quality of life questionnaire (RQLQ) before and after acupuncture therapy. Results: Based upon patients' response to the RQLQ, acupuncture therapy significantly reduced allergic rhinitis symptoms, including nasal symptoms, non-hay fever symptoms, and sleep and practical problems (associated with daily activities). In addition, expression of interleukin-1 receptor-α (IL1R1) in peripheral blood was significantly decreased at 2 hours, 24 hours, and 4 weeks after acupuncture treatment in these patients. Conclusions: To our knowledge, this is the first report of cDNA microarray analysis of differential gene expression in the peripheral blood of patients with allergic rhinitis before and after acupuncture treatment. Our data suggest that the balance between T-helper 1 and T-helper 2 cell-derived proinflammatory versus anti-inflammatory cytokines might be improved by acupuncture treatment.",
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