DNA methyltransferase gene dDnmt2 and longevity of Drosophila

Meng Jau Lin, Lin Ya Tang, M. Narsa Reddy, C. K.James Shen

研究成果: 雜誌貢獻文章同行評審

81 引文 斯高帕斯(Scopus)

摘要

The DNA methylation program of the fruit fly Drosophila melanogaster is carried out by the single DNA methyltransferase gene dDnmt2, the function of which is unknown before. We present evidence that intactness of the gene is required for maintenance of the normal life span of the fruit flies. In contrast, overexpression of dDnmt2 could extend Drosophila life span. The study links the Drosophila DNA methylation program with the small heatshock proteins and longevity/aging and has interesting implication on the eukaryotic DNA methylation programs in general.

原文英語
頁(從 - 到)861-864
頁數4
期刊Journal of Biological Chemistry
280
發行號2
DOIs
出版狀態已發佈 - 一月 14 2005
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 分子生物學
  • 細胞生物學

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