@article{c9b2977192964cbeb345fa25ffa7c111,
title = "DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers",
abstract = "Epigenetic modifications play important roles in regulating carcinogenesis, and specific epigenetic modifications have emerged as potential tumor markers. Herein, we summarize several types of epigenetic modifications, explore the role played by epigenetic modifications in gene regulation, and describe the patterns of epigenetic modifications in cancers. Since epigenetic modifications have been reported to regulate the Warburg effect in cancers, the roles of epigenetic modifications in sugar metabolism are discussed. In addition, oxidative stress may play an important role in carcinogenesis, and the role of oxidative stress and epigenetic modification in carcinogenesis is addressed. We also discuss the role of epigenetic modifications as therapeutic targets. Finally, the synergistic effects of the combined treatment of epigenetic regulator and anticancer drugs for cancer therapy are described.",
keywords = "Acetylation, Epigenetic modification, Histone, Methylation, Sugar metabolism",
author = "Yen, {Ching Yu} and Huang, {Hurng Wern} and Shu, {Chih Wen} and Hou, {Ming Feng} and Yuan, {Shyng Shiou F.} and Wang, {Hui Ru} and Chang, {Yung Ting} and Farooqi, {Ammad Ahmad} and Tang, {Jen Yang} and Chang, {Hsueh Wei}",
note = "Funding Information: This work was partly supported by funds of the Ministry of Science and Technology ( 104-2320-B-037-013-MY3 ), the ChiMei-KMU Joint Project ( 104CM-KMU-02 ), the National Sun Yat-sen University -KMU Joint Research Project (# NSYSU-KMU 105-P022 ), the Kaohisung Medical University “Aim for the Top Universities Grant, Grant No. KMU-TP104PR02 ”, the Kaohsiung Municipal Ta-Tung Hospital Grant ( kmtth-104-003 ), and the Health and welfare surcharge of tobacco products, the Ministry of Health and Welfare, Taiwan , Republic of China ( MOHW104-TDU-B-212-124-003 ).",
year = "2016",
month = apr,
day = "10",
doi = "10.1016/j.canlet.2016.01.036",
language = "English",
volume = "373",
pages = "185--192",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",
}
