DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers

Ching Yu Yen, Hurng Wern Huang, Chih Wen Shu, Ming Feng Hou, Shyng Shiou F Yuan, Hui Ru Wang, Yung Ting Chang, Ammad Ahmad Farooqi, Jen Yang Tang, Hsueh Wei Chang

研究成果: 雜誌貢獻文章

40 引文 斯高帕斯(Scopus)

摘要

Epigenetic modifications play important roles in regulating carcinogenesis, and specific epigenetic modifications have emerged as potential tumor markers. Herein, we summarize several types of epigenetic modifications, explore the role played by epigenetic modifications in gene regulation, and describe the patterns of epigenetic modifications in cancers. Since epigenetic modifications have been reported to regulate the Warburg effect in cancers, the roles of epigenetic modifications in sugar metabolism are discussed. In addition, oxidative stress may play an important role in carcinogenesis, and the role of oxidative stress and epigenetic modification in carcinogenesis is addressed. We also discuss the role of epigenetic modifications as therapeutic targets. Finally, the synergistic effects of the combined treatment of epigenetic regulator and anticancer drugs for cancer therapy are described.
原文英語
頁(從 - 到)185-192
頁數8
期刊Cancer Letters
373
發行號2
DOIs
出版狀態已發佈 - 四月 10 2016

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Yen, C. Y., Huang, H. W., Shu, C. W., Hou, M. F., Yuan, S. S. F., Wang, H. R., Chang, Y. T., Farooqi, A. A., Tang, J. Y., & Chang, H. W. (2016). DNA methylation, histone acetylation and methylation of epigenetic modifications as a therapeutic approach for cancers. Cancer Letters, 373(2), 185-192. https://doi.org/10.1016/j.canlet.2016.01.036