DNA looping alters local DNA conformation during transcription

Hai Young Wu, Leroy-Fong Liu

研究成果: 雜誌貢獻文章

41 引文 斯高帕斯(Scopus)

摘要

The effect of protein-mediated DNA looping on local DNA conformation during active transcription was studied using the lac repressor-operator system. Our results suggest that lac repressor-mediated DNA looping within a plasmid DNA molecule containing two lac repressor binding sequences in vivo effectively separates plasmid DNA into two topological domains. Supercoils generated by transcription within each topological domain can be rapidly removed by DNA topoisomerase I.

原文英語
頁(從 - 到)615-622
頁數8
期刊Journal of Molecular Biology
219
發行號4
DOIs
出版狀態已發佈 - 六月 20 1991
對外發佈Yes

ASJC Scopus subject areas

  • Virology

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