DNA aptamers as potential anti-HIV agents

Shan Ho Chou, Ko Hsin Chin, Andrew H.J. Wang

研究成果: 雜誌貢獻簡短的問卷調查同行評審

63 引文 斯高帕斯(Scopus)

摘要

Guanine (G)-rich DNA sequences can adopt stable G-quadruplex structures by G-tetrad hydrogen-bonding and hydrophobic stacking. Recently, it has been shown that a DNA sequence forms an aptamer (termed 93del) and adopts a novel dimeric quadruplex folding topology in K+ solution. This aptamer exhibits anti-HIV1 integrase activity in the nanomolar range in vitro. A docking-based model of the 93del-integrase complex positions the DNA aptamer within a channel of the tetrameric integrase. This mutual fitting blocks several catalytic amino acid residues that are essential for integrase function, and accounts for the anti-HIV1 activity of the 93del aptamer.

原文英語
頁(從 - 到)231-234
頁數4
期刊Trends in Biochemical Sciences
30
發行號5
DOIs
出版狀態已發佈 - 5月 2005
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 分子生物學

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