Diverse apoptotic pathways in enterovirus 71-infected cells

Shih Cheng Chang, Jing Yi Lin, Lily Yen Cheng Lo, Mei Ling Li, Shin Ru Shih

研究成果: 雜誌貢獻文章同行評審

72 引文 斯高帕斯(Scopus)


Mechanisms related to the neuropathogenesis of enterovirus 71 infection remain unclear. This investigation conducts a comprehensive study of the apoptotic pathways in neural and non-neural cells following enterovirus 71 infection. Infections with enterovirus 71 not only induce classical cytopathic effects in SF268 (human glioblastoma), SK-N-MC (human neuroblastoma), RD, and Vero cells, but also induce classic signs of apoptosis in all cells, including DNA fragmentation and phosphatidylserine translocation. Apoptosis has also been caused by the efflux of cytochrome c from mitochondria, and subsequently by cleavage of caspase 9 in all cells. Activation of caspase 8 followed by cleavage of the proapoptotic protein Bid only occurs in non-neural cells. Results of this study demonstrate that a mitochondrial pathway of apoptosis mediated by activation and cleavage of caspase 9 is a main pathway in enterovirus 71-induced apoptosis, especially for enterovirus 71-infected neural cells.

頁(從 - 到)338-349
期刊Journal of NeuroVirology
出版狀態已發佈 - 12月 2004

ASJC Scopus subject areas

  • 病毒學
  • 神經病學(臨床)


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