Distribution of Th1 and Th2 cell populations in human peripheral and decidual T cells from normal and anembryonic pregnancies

Hong Nerng Ho, Kuang Han Chao, Hsin Fu Chen, Shee Uan Chen, Ming Yih Wu, Yu Shih Yang

研究成果: 雜誌貢獻文章同行評審

25 引文 斯高帕斯(Scopus)

摘要

Objective: To examine whether maternal immune responses during normal pregnancy are Th2 biased and whether there are specific changes when anembryonic pregnancy occurs. Design: Prospective study. Setting: Department of Obstetrics and Gynecology at a university hospital. Patient(s): We studied 32 pregnant women receiving elective abortions of normal pregnancies and 35 women with anembryonic pregnancies between 6 weeks and 10 weeks of gestational age. Intervention(s): Using the multilabeling capability of three-color flow cytometry, it is possible to measure intracellular cytokines and cell surface markers simultaneously to determine which cells are the cytokine-producing cells. Main Outcome Measure(s): We examined the extent and proportion of mononuclear cells expressing specific T-cell surface markers and cytokines, interferon γ, and interleukin 4 in the peripheral blood and deciduae. Secreted cytokines in the supernatants after 24-hour culture were also compared. Result(s): During the unstimulated status, the proportion of IL-4-secreting cells significantly exceeded that of IFN-γ-secreting cells in the peripheral blood and decidua in normal pregnancies and was significantly decreased when anembryonic pregnancies occurred. Consequently, the Th1/Th2 ratios were increased during anembryonic pregnancies. However, after 24-hour culture, only another Th2-type cytokine, IL-10, was markedly increased and exceeded IFN-γ secretion in cultures from both the peripheral blood and decidua in normal pregnancies. Conclusion(s): The decidual T lymphocytes are Th2 predominant. When anembryonic pregnancy occurs, this Th2 predominance disappears.
原文英語
頁(從 - 到)797-803
頁數7
期刊Fertility and Sterility
76
發行號4
DOIs
出版狀態已發佈 - 十月 16 2001
對外發佈

ASJC Scopus subject areas

  • 婦產科

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