Distribution of HLA-DQB1 alleles in patients with Kleine-Levin syndrome

Chi Jung Huang, Hung Tsai Liao, Geng Chang Yeh, Kun Long Hung

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

Kleine-Levin syndrome (KLS) is a rare disorder characterized by recurrent episodes of hypersomnia, cognitive or behavior disturbances, compulsive eating behavior, and hypersexuality. The etiology of KLS remains unknown even though its clinical symptoms suggest an underlying autoimmune process. In this study, we analyzed the human leukocyte antigen (HLA) typing alleles in Taiwanese patients with KLS using the polymerase chain reaction sequence-specific priming technique. We report that an immunoresponsive HLA-DQB1, DQB10602, was detected in significant quantities in patients with KLS (three of 12, p = 0.046) and could elevate the risk of KLS (odds ratio, 1.143; 95% confidence interval, 0.0982-1.329). In conclusion, an identification of genomic susceptibility to KLS will be helpful in determining the immunospecific targeted therapies for patients with KLS.

原文英語
頁(從 - 到)628-630
頁數3
期刊Journal of Clinical Neuroscience
19
發行號4
DOIs
出版狀態已發佈 - 4月 2012

ASJC Scopus subject areas

  • 手術
  • 神經內科
  • 神經病學(臨床)
  • 生理學(醫學)

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